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FGF6 Protein (AA 41-208)

FGF6 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
产品编号 ABIN2017827
发货至: 中国
  • 抗原 See all FGF6 蛋白
    FGF6 (Fibroblast Growth Factor 6 (FGF6))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 41-208
    宿主
    • 4
    • 2
    • 1
    • 1
    资源
    • 8
    大肠杆菌(E. Coli)
    产品特性
    ED50 < 2.5 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence 1 xg/mL heparin, corresponding to a specific activity of > 4x 10^5 units/mg.
    AA 41-208, expressed with an N-terminal Met.
    纯度
    > 95 % as analyzed by SDS-PAGE and HPLC.
    内毒素水平
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product FGF6 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstituted in ddH2O at 100 μg/mL.
    缓冲液
    Lyophilized after extensive dialysis against PBS.
    储存条件
    -80 °C
    储存方法
    Lyophilized recombinant human Fibroblast Growth Factor-6 (rhFGF-6) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhFGF-6 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    有效期
    6 months
  • 抗原
    FGF6 (Fibroblast Growth Factor 6 (FGF6))
    别名
    Fibroblast Growth Factor-6 (FGF-6) (FGF6 产品)
    别名
    FGF6 Protein, hst2 Protein, fgf-6 Protein, hbgf-6 Protein, HBGF-6 Protein, HST2 Protein, Fgf-6 Protein, HSTF-2 Protein, fgf4 Protein, fgf6 Protein, fibroblast growth factor 6 Protein, fibroblast growth factor 6a Protein, FGF6 Protein, fgf6 Protein, Fgf6 Protein, fgf6a Protein
    背景
    Fibroblast Growth Factor-6 (FGF-6) is a cytokine belonging to the heparin-binding FGF family, and is structurally related to other members of FGF family, particularly FGF-4. In vivo, FGF-6 exhibits an expression profile predominantly restricted tothe myogenic lineage, and it preferentially binds to two of the FGF receptors: FGFR1 and FGFR4. FGF-6 functions in muscle regeneration, myoblast proliferation and migration, and muscle differentiation in a dose-dependent manner. In vivo high concentration of recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4, respectively, as FGFR1 promotes the proliferation while FGFR4 promotes the differentiation in the muscle. Besides its dual function in muscle regeneration, FGF-6 may act as a regulator of bone metabolism as well.Recombinant human Fibroblast Growth Factor-6 (rhFGF-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-6 has a molecular mass of 18.8 kDa analyzed by reducing SDS-PAGE.
    Synonyms: Fibroblast Growth Factor-6, HBGF-6, HST-2
    分子量
    18.8 kDa, observed by reducing SDS-PAGE.
    UniProt
    P10767
    途径
    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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