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GDF10 Protein (AA 369-478)

GDF10 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as analyzed by SDS-PAGE and HPLC.
产品编号 ABIN2017700
发货至: 中国
  • 抗原 See all GDF10 蛋白
    GDF10 (Growth Differentiation Factor 10 (GDF10))
    蛋白类型
    Recombinant
    产品特性
    AA 369-478
    宿主
    • 5
    • 2
    • 1
    • 1
    资源
    • 5
    • 2
    • 2
    大肠杆菌(E. Coli)
    产品特性
    AA 369-478, expressed with an N-terminal Met.
    纯度
    > 95 % as analyzed by SDS-PAGE and HPLC.
    内毒素水平
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product GDF10 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstituted in 4 mM HCl at 100 μg/mL.
    缓冲液
    Lyophilized after extensive dialysis against 4 mM HCl.
    储存条件
    -80 °C
    储存方法
    Lyophilized recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhBMP-3B remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    有效期
    6 months
  • 抗原
    GDF10 (Growth Differentiation Factor 10 (GDF10))
    别名
    Bone Morphogenetic Protein-3B (BMP-3B) (GDF10 产品)
    别名
    GDF10 Protein, BMP-3b Protein, BMP3B Protein, Bmp3b Protein, bmp3b Protein, gdf-10 Protein, xBMP-3b Protein, growth differentiation factor 10 Protein, growth differentiation factor 10 L homeolog Protein, GDF10 Protein, Gdf10 Protein, gdf10.L Protein
    背景
    Bone Morphogenetic Protein-3B (BMP-3B) , also known as Growth/Differentiation Factor 10 (GDF-10), is a cytokine belonging to the Transforming Growth Factor beta (TGF-beta) superfamily. BMP-3B contains the cystine knot motif shared by other TGF-beta family members. BMP-3B was originally identified by PCR based on the BMP-3 sequence, and shares 83 % identity with BMP-3. BMP-3B and BMP-2 act as mutual antagonists, as they compete for the availability of signaling protein Smad4. In vivo, BMP-3B is highly expressed in brain, lungs, and bone tissues. The functions of BMP-3B include acting as a dorsaling factor in head development, inhibition of adipogenesis in adipocytes, and induction of bone formation. BMP-3B is down-regulated in lung cancer patient samples, indicating its potential antitumor activity. Recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 111 amino acids each. rhBMP-3B has a molecular mass of 25.1 kDa analyzed by non-reducing SDS-PAGE.
    Synonyms: Osteogenin, BMP-3A
    分子量
    25.1 kDa, observed by non-reducing SDS-PAGE.
    UniProt
    P55107
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