ED50 <0.5 ng/mL, measured by a cell proliferation assay using3T3cells, corresponding to a specific activity of>2× 10^6 units/mg. AA 32-111, expressed with an N-terminal Met.
Lyophilized after extensive dialysis against 50 mM Tris, 300 mM NaCl, pH 9.0.
储存条件
-80 °C
储存方法
Lyophilized recombinant mouse Betacellulin (rmBetacellulin) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmBetacellulin remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
BTC Protein, LOC100228121 Protein, probetacellulin Protein, Bcn Protein, betacellulin Protein, betacellulin, epidermal growth factor family member Protein, BTC Protein, LOC100228121 Protein, Btc Protein
背景
Betacellulin is a pleiotropic cytokine that belongs to the Epidermal Growth Factor (EGF) family. Like other members of the EGF family, Betacellulin possesses a conserved sequence of 35-40 amino acids which contain 3 disulfide bonds formed by 6 cysteines. Betacellulin is unique in the EGF family since it can bind and activate a broad spectrum of ErbB receptors. Functionally, Betacellulin plays a role in the development of the pancreas by activating signaling pathways beneficial for the function, survival and regeneration of pancreatic beta-cells. Additionally, Betacellulin has potential angiogenic activities and is important for the growth, development and repair of certain tissues.Recombinant mouse Betacellulin (rmBetacellulin) produced in E. coli is a single non-glycosylated polypeptide chain containing 81 amino acids. A fully biologically active molecule, rmBetacellulin has a molecular mass of 9.2 kDa analyzed by reducing SDS-PAGE. Synonyms: BTC