CHN Protein, CSMF Protein, MINOR Protein, NOR1 Protein, TEC Protein, AI573420 Protein, NOR-1 Protein, Nor1 Protein, NOR-2 Protein, NR4A3 Protein, Nr4a3 Protein, nuclear receptor subfamily 4 group A member 3 Protein, nuclear receptor subfamily 4, group A, member 3 Protein, NR4A3 Protein, Nr4a3 Protein, nr4a3 Protein
背景
Synonyms: CHN,CSMF,MINOR,NOR1,TEC Gene Description: nuclear receptor subfamily 4, group A, member 3 Gene Name: NR4A3 Gene Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Four transcript variants encoding three distinct isoforms have been identified for this gene.