zgc:56315 Protein, tfar19 Protein, DKFZp468P187 Protein, TFAR19 Protein, 2200003D22Rik Protein, AA408513 Protein, Tfar19 Protein, programmed cell death 5 Protein, programmed cell death 5 S homeolog Protein, DNA-binding protein Protein, pdcd5 Protein, PDCD5 Protein, pdcd5.S Protein, SSO_RS01750 Protein, Pdcd5 Protein
背景
Programmed cell death 5, PDCD5, also known as TF1 cell apoptosis-related gene 19, TFAR19, this gene encodes a protein of 125 amino acids, with an ATG initiation codon at nucleotides 25-27. It contains a cAMP- and cGMP-dependent protein kinase phosphorylation site, multiple protein kinase C phosphorylation sites, and a casein kinase II phosphorylation site. Human TFAR19 encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice. TFAR19 exhibits a ubiquitous expression pattern and its expression is upregulated in the tumor cells undergoing apoptosis. Overexpression of TFAR19 in tumor cells enhances apoptosis triggered by growth factor or serum deprivation. So, it may play a general role in the apoptotic process.