PEA15 Protein (AA 1-130)
PEA15
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
> 95 % as determined by reducing SDS-PAGE.
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- 抗原 See all PEA15 蛋白
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-130
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15
- 序列
- GSHMAEYGTL LQDLTNNITL EDLEQLKSAC KEDIPSEKSE EITTGSAWFS FLESHNKLDK DNLSYIEHIF EISRRPDLLT MVVDYRTRVL KISEEDELDT KLTRIPSAKK YKDIIRQPSE EEIIKLAPPP KKA
- 产品特性
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala130) of Human PEA15.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product PEA15 蛋白
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phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (GST tag)
PEA15 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
phosphoprotein Enriched in Astrocytes 15 (PEA15) protein (Myc-DYKDDDDK Tag)PEA15 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- 4 °C/-20 °C/-80 °C
- 储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - 有效期
- 3 months
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- 抗原
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
- 别名
- PEA15 (PEA15 产品)
- 别名
- HMAT1 Protein, HUMMAT1H Protein, MAT1 Protein, MAT1H Protein, PEA-15 Protein, PED Protein, Pea15a Protein, PEA15 Protein, DKFZp459O1410 Protein, proliferation and apoptosis adaptor protein 15 Protein, phosphoprotein enriched in astrocytes 15 Protein, proliferation and apoptosis adaptor protein 15 L homeolog Protein, Astrocytic phosphoprotein PEA-15 Protein, PEA15 Protein, Pea15 Protein, pea15.L Protein, pea15 Protein
- 背景
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Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
Alternative Names: Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15 - 分子量
- 15.3 kDa
- UniProt
- Q15121
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