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HSPD1 Protein (partial)

HSPD1 宿主: Bacteria 宿主: 大肠杆菌(E. Coli) Recombinant >90% WB, SDS, ELISA, Func
产品编号 ABIN1686691
发货至: 中国
  • 抗原 See all HSPD1 蛋白
    HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
    蛋白类型
    Recombinant
    产品特性
    partial
    宿主
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Bacteria
    资源
    • 16
    • 2
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    应用范围
    Western Blotting (WB), SDS-PAGE (SDS), ELISA, Functional Studies (Func)
    序列
    EDPYEKIGAE LVKEVAKKTD DVAGDGTTTA TVLAQALVRE GLRNVAAGAN PLGLKRGIEK AVEKVTETLL KGAKEVETKE QIAATAAISA GDQSIGDLIA EAMDKVGNEG VITVEESNTF GLQLELTEGM RFDKGYISGY FVTDPERQEA VLEDPYILLV SSKVSTVKDL LPLXXXXXXX GKPLLIIAED VEGEALSTLV
    特异性
    ~65 kDa
    纯化方法
    Multi-Step Purified
    纯度
    >90%
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    This product has been certified >90% pure using SDS-PAGE analysis.

    限制
    仅限研究用
  • 浓度
    Lot specific
    缓冲液
    10 mM Tris pH 8, 105 mM NaCl, 5 mM EDTA
    储存条件
    -20 °C
  • Sun, Shen, Liu, Tan, Tian, Luo, Lai, Dai, Guo: "Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein." in: Atherosclerosis, Vol. 237, Issue 2, pp. 853-61, (2014) (PubMed).

    Adamus, Bonnah, Brown, David: "Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy." in: BMC ophthalmology, Vol. 13, pp. 48, (2013) (PubMed).

  • 抗原
    HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
    Abstract
    HSPD1 产品
    背景
    HSP65 isolated from Mycobacterium bovis BCG, is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In addition to its role as a heat shock protein, HSP60 functions as a chaperonin to assist in folding linear amino acid chains into their respective three-dimensional structure. HSP60s are a ubiquitous class of HSPs that specifically promote the folding and assembly of cellular polypeptides in an ATP-dependent manner (1). Specifically, sequence comparison of HSP65 from different mycobacterium strains showed that the protein sequence of M. bovis BCG is identical to that of M. tuberculosis, and very similar to that of M. leprae, the pathogens that cause tuberculosis and tuberculoid leprosy, respectively (2,4). Mycobacterium bovis BCG HSP65 was identified as the immunodominant antigen during mycobacterial diseases and vaccination. It is also believed to be the antigen that induces autoimmune disease, such as adjuvant arthritis in rats (5, 6).
    分子量
    approx. 65 kDa
    UniProt
    Q1EHB9
    途径
    Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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