IL13RA2 Protein (Extracellular Domain)
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- 抗原 See all IL13RA2 蛋白
- IL13RA2 (Interleukin 13 Receptor, alpha 2 (IL13RA2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Extracellular Domain
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宿主
- 小鼠
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资源
- HEK-293T Cells
- 特异性
- Optimized DNA sequence encoding extracellular domain of mouse IL-13 receptor alpha2 including an His tag was expressed in HEK293 cells.
- 产品特性
- Recombinant mouse IL-13 receptor alpha is a monomer protein consisting of 325 amino acid residue subunits, due to glycosylation migrates as an approximately 50kDa protein on SDS-PAGE.
- 纯度
- > 98 %, as determined by SDS-PAGE and HPLC
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
- Top Product
- Discover our top product IL13RA2 蛋白
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- 说明
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The activity was measured by its ability to inhibit proliferation of IL-13 dependent TF1 Cells. The ED50 was determined to be 0.1-0.5 µg/mL.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS solution, pH7.2
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
- 有效期
- 12-24 months
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- 抗原
- IL13RA2 (Interleukin 13 Receptor, alpha 2 (IL13RA2))
- 别名
- IL13RA2 (IL13RA2 产品)
- 别名
- il-13ra2 Protein, sb:cb602 Protein, si:dkeyp-110c7.6 Protein, CD213A2 Protein, CT19 Protein, IL-13R Protein, IL13BP Protein, CD213a2 Protein, IL-13R-alpha-2 Protein, IL13RA2 Protein, interleukin 13 receptor, alpha 2 Protein, interleukin 13 receptor subunit alpha 2 Protein, interleukin 13 receptor subunit alpha 2 S homeolog Protein, il13ra2 Protein, IL13RA2 Protein, il13ra2.S Protein, Il13ra2 Protein
- 背景
- PDGF is synthesized mainly by megakaryocytes. It is stored in the alpha granules of platelets from which it is released after cell activation of platelets. Platelets synthesize a mixture of the three possible isoforms (BB,AB,AA) while fibroblasts stimulated with EGF synthesize AA homodimers. PDGF receptors are expressed in fibroblasts, osteoblasts, chondroblasts, smooth muscle cells, glial cells, and endothelial cells. Two related receptors, are PDGFRalpha (CD140a) or PDGFRbeta ( CD140b). In contrast to many other cytokines PDGF is not released into the circulation. PDGF binds to several plasma proteins and also to proteins of the extracellular matrix which facilitates local concentration of the factor. The factor functions as a local autocrine and paracrine growth factor. In the adult organism PDGF is involved in wound healing processes. The aberrant expression of PDGF is observed with vascular proliferative diseases such as atherosclerosis. PDGF regulates the synthesis of its own receptor and also influences the expression of membrane receptors for IL1, EGF, 5-Hydroxytryptamine, LDL, transferrin, and muscarinergic receptor.
- UniProt
- O88786
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