CD31 Protein (C-Term, Extracellular Domain)
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- 抗原 See all CD31 (PECAM1) 蛋白
- CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))
- 蛋白类型
- Recombinant
- 产品特性
- C-Term, Extracellular Domain
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宿主
- 小鼠
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资源
- HEK-293T Cells
- 特异性
- Optimized DNA sequence encoding extracellular domain of mouse CD31 including a C-terminal 6His tag was expressed in HEK293 cells.
- 产品特性
- Recombinant mouse CD31 (PECAM-1) is a monomer protein consisting of 585 amino acid residue subunits, due to glycosylation migrates as an approximately 100 kDa protein on SDS-PAGE.
- 纯度
- > 95 %, as determined by SDS-PAGE and HPLC
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
- Top Product
- Discover our top product PECAM1 蛋白
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Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-601) protein (His tag)
PECAM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 18-590) protein (His tag)PECAM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-602) protein (His tag)PECAM1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-601) protein (PE,Fc Tag)PECAM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-150) protein (His tag)PECAM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 29-738) protein (GST tag)PECAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 1-738) protein (GST tag)PECAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Platelet/endothelial Cell Adhesion Molecule (PECAM1) proteinPECAM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-601) protein (Fc Tag)PECAM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 缓冲液
- PBS solution, pH7.2
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
- 有效期
- 12-24 months
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- 抗原
- CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))
- 别名
- CD31 (PECAM1 产品)
- 别名
- CD31 Protein, CD31/EndoCAM Protein, GPIIA' Protein, PECA1 Protein, PECAM-1 Protein, endoCAM Protein, C85791 Protein, Cd31 Protein, Pecam Protein, platelet/endothelial cell adhesion molecule 1 Protein, platelet and endothelial cell adhesion molecule 1 Protein, pecam1 Protein, PECAM1 Protein, Pecam1 Protein
- 背景
- Oncostatin M is produced by monocytes and T-cells after cell activation, adherent macrophages, and various T-cell lines. Oncostatin M is a member of the IL6-related cytokine subfamily that includes IL6, IL11, LIF, CNTF and CT-1. Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines. When gp130 dimerizes with LIF receptor beta subunit this generates the high affinity type 1 OSM receptor. When gp130 dimerizes with a protein known as OSM receptor beta this generates the type OSM receptor. Both OSM receptors activate the receptor-associated Janus kinases JAK1, JAK2, and TYK2. Signaling also involves the transcriptional activators STAT3 and STAT5b (see also: STAT proteins). The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. Oncostatin M inhibits the growth of several tumor cell lines (A375 melanoma, lung carcinomas). The antiproliferative activity of oncostatin M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular smooth muscle cells, and some normal cell lines. Oncostatin can inhibit the proliferation of murine M1 myeloid leukemic cells and induces their differentiation into macrophage-like cells, a function shared by LIF, G-CSF, and IL6.
- UniProt
- P16284
- 途径
- Regulation of Actin Filament Polymerization
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