GREM1 蛋白
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- 抗原 See all GREM1 蛋白
- GREM1 (Gremlin 1 (GREM1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 原理
- Gremlin-1
- 序列
- MKKKGSQGAI PPPDKAQHND SEQTQSPPQP GSRTRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTTMM VTLNCPELQP PTKKKRVTRV KQCRCISIDL D
- 特异性
- Chromosomal location:2 E4, 2 64.5 cM
- 产品特性
- Length (aa):161
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product GREM1 蛋白
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Gremlin 1 (GREM1) (Active) protein
GREM1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） WB, SDS Active
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Gremlin 1 (GREM1) (AA 25-184) protein (His-IF2DI Tag)GREM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Gremlin 1 (GREM1) (AA 75-184) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-124) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 1-184) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (His tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- 说明
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Cytokines & Growth Factors
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Mouse Grem-1 should be reconstituted in 50 mM acetic acid or water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- 缓冲液
- 50 mM acetic acid
- 储存条件
- RT,0 °C
- 储存方法
- The lyophilized mouse Grem-1, though stable at room temperature, is best stored desiccated below 0°C
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- 抗原
- GREM1 (Gremlin 1 (GREM1))
- 别名
- Gremlin-1 (GREM1 产品)
- 别名
- grem1 Protein, MGC136702 Protein, zgc:136702 Protein, GREM1 Protein, drm Protein, pig2 Protein, dand2 Protein, ihg-2 Protein, gremlin Protein, Cktsf1b1 Protein, Drm Protein, Grem Protein, ld Protein, gremlin-1 Protein, CKTSF1B1 Protein, DAND2 Protein, DRM Protein, GREMLIN Protein, IHG-2 Protein, cktsf1b1 Protein, gremlin 1a, DAN family BMP antagonist Protein, gremlin 1, DAN family BMP antagonist Protein, gremlin 1 Protein, gremlin 1, DAN family BMP antagonist L homeolog Protein, grem1a Protein, GREM1 Protein, LOC662541 Protein, grem1 Protein, Grem1 Protein, grem1.L Protein
- 背景
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Gremlin was identified in a Xenopus expression cloning screen as a dorsalizing factor that can induce a secondary axis. A rat homolog, called Drm, was identified as a cDNA that was down regulated in v Mos transfected cells. Gremlin/Drm belongs to the DAN family of secreted glycoproteins that are BMP antagonists. Other members of the family include: Cerberus, Dante, PRDC, Caronte and DAN. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFβ superfamily ligands. In vitro, Gremlin/Drm binds BMP4 and BMP2 indicating that it might interfere with BMP signaling. Gremlin/Drm acts as a BMP2/ 4 antagonist in a variety of tissues and developmental processes including: Xenopus animal cap explants, chick limb bud outgrowth and chondrogenesis, murine lung branching morphogenesis, and osteogenic differentiation of mouse myoblasts and bone marrow stromal cells. In addition, expression of Gremlin/Drm has been shown to be down-regulated in a wide range of human cancer cell lines. Mouse, human, chick and Xenopus homologs of Gremlin share over 80 % amino acid identity. It is likely that various DAN family members and other BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFβ superfamily ligands.
Synonyms: Grem1, ld, Drm, Cktsf1b1 - 分子量
- 20.7 kDa
- 基因ID
- 23892
- NCBI登录号
- NM_011824, NP_035954
- UniProt
- O70326
- 途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
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