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Flagellin Protein (FliC)

FliC 宿主: 人, 小鼠 宿主: Salmonella typhimurium >95 % (SDS-PAGE) SDS Active
产品编号 ABIN1344457
发货至: 中国
  • 抗原 See all Flagellin (FliC) 蛋白
    Flagellin (FliC)
    生物活性
    Active
    宿主
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    资源
    • 7
    • 5
    • 1
    Salmonella typhimurium
    应用范围
    SDS-PAGE (SDS)
    特异性
    Binds to human and mouse TLR5 (Toll-like receptor 5).
    交叉反应
    人, 小鼠
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product FliC 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin (high Purity) at a concentration of 5-50ng /ml and in vivo at a starting concentration of 0.1-1μg /mouse.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute with 100 μL sterile water.
    浓度
    Lot specific
    缓冲液
    Lyophilized. Contains PBS.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • 抗原
    Flagellin (FliC)
    别名
    Flagellin (FliC 产品)
    别名
    hag Protein, flaG Protein, flagellin Protein, flagellin (flic) Protein, flagellin E Protein, flagellin protein flic Protein, fliC Protein, FliC Protein, fliC+F2048 Protein, CJJ81176_1339 Protein, C8J_1256 Protein
    背景
    Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
    UniProt
    P06179
    途径
    Inflammasome
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