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IL-33 Protein (AA 109-266)

IL33 宿主: 人, 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant >95 % (SDS-PAGE) SDS Active
产品编号 ABIN1343980
发货至: 中国
  • 抗原 See all IL-33 (IL33) 蛋白
    IL-33 (IL33) (Interleukin 33 (IL33))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 109-266
    宿主
    • 17
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    资源
    • 24
    • 8
    • 2
    • 2
    • 1
    大肠杆菌(E. Coli)
    应用范围
    SDS-PAGE (SDS)
    特异性
    Binds to mouse and human ST2.
    交叉反应
    人, 小鼠
    产品特性
    Mouse IL-33 (aa 109-266) is untagged.
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IL33 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Activates ST2-dependent NF-kappaB pathway.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute with 100 μL sterile water.
    浓度
    Lot specific
    缓冲液
    Lyophilized. Contains PBS.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • 抗原
    IL-33 (IL33) (Interleukin 33 (IL33))
    别名
    IL-33 (IL33 产品)
    别名
    IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
    背景
    Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
    分子量
    ~18kDa
    UniProt
    Q2YEJ4
    途径
    Production of Molecular Mediator of Immune Response
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