STUB1 Protein (AA 1-303)
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- 抗原 See all STUB1 蛋白
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-303
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP
- 序列
- MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY
- 产品特性
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Tyr303) of Human CHIP.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product STUB1 蛋白
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)
STUB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 204-303) protein (GST tag)STUB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- -80 °C
- 储存方法
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - 有效期
- 6 months
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- 抗原
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
- 别名
- chip (STUB1 产品)
- 别名
- CHIP Protein, HSPABP2 Protein, NY-CO-7 Protein, SDCCAG7 Protein, UBOX1 Protein, 0610033N24Rik Protein, 2210017D18Rik Protein, 2310040B03Rik Protein, AW046544 Protein, Chip Protein, wu:fc22f04 Protein, zgc:56076 Protein, STUB1 Protein, chip Protein, ATCHIP Protein, CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN Protein, carboxyl terminus of HSC70-interacting protein Protein, STIP1 homology and U-box containing protein 1 Protein, STIP1 homology and U-Box containing protein 1 Protein, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog Protein, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Protein, STIP1 homology and U box-containing protein 1 Protein, carboxyl terminus of HSC70-interacting protein Protein, STUB1 Protein, Stub1 Protein, stub1 Protein, stub1.L Protein, LOC100282870 Protein, CHIP Protein
- 背景
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E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
Alternative Names: E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP - 分子量
- 34.86 kDa
- UniProt
- Q9UNE7
- 途径
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
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