recombinant sTNFR-I comprises a 161 amino acid fragment (41-201) corresponding to the mature sTNFR-I protein and is expressed in E. coli with an aminoterminal hexahistidine tag.
Two types of soluble TNF receptors (sTNFR-I and sTNFRII) have been identified, which act to neutralize the biological activities of TNF alpha and TNF beta. Levels of these soluble receptors appear to arise as a result of shedding of the extracellular domains of the membrane bound receptors. Elevated levels of soluble TNF receptors have been found in the amniotic fluid of pregnant women.,Soluble tumour necrosis factor receptor-1, Tumour necrosis factor receptor subfamily member 1A (TNFRSF1A), Tumour necrosis factor binding protein I (TNFBPI), Tumour necrosis factor receptor type I (TNFRI), Tumour necrosis factor-alpha receptor (TNFAR), CD120a antigen, p55, p55-R, p60, MGC19588.