This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008].
PRPS1L1
适用: 人
WB, ICC, IF
宿主: 兔
Polyclonal
unconjugated
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Venter, Adams, Myers, Li, Mural, Sutton, Smith, Yandell, Evans, Holt, Gocayne, Amanatides, Ballew, Huson, Wortman, Zhang, Kodira, Zheng, Chen, Skupski, Subramanian, Thomas, Zhang, Gabor Miklos et al.: "The sequence of the human genome. ..." in: Science (New York, N.Y.), Vol. 291, Issue 5507, pp. 1304-51, (2001) (PubMed).
Taira, Iizasa, Shimada, Kudoh, Shimizu, Tatibana: "A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon." in: The Journal of biological chemistry, Vol. 265, Issue 27, pp. 16491-7, (1990) (PubMed).