Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 产品
(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].
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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 抗体
High quality antibodies with extensive validation data.
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D ELISA试剂盒
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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 蛋白
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Recommended Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN740415
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7165942
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN563650
Quantity
100 μg
Datasheet
Datasheet
Recommended Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958950
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Sandwich ELISA
Validations
Cat. No.
ABIN422939
Quantity
96 tests
Datasheet
Datasheet
Recommended Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 蛋白
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Reactivity
Source
Validations
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Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315910
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315909
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN5623952
Quantity
50 μg
Datasheet
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Latest Publications for our Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Products
: "Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway." in: Oncology letters, Vol. 12, Issue 6, pp. 4605-4612, (2017) (PubMed).: "p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 896-904, (2012) (PubMed).
: "HDM2 promotes WIP1-mediated medulloblastoma growth." in: Neuro-oncology, Vol. 14, Issue 4, pp. 440-58, (2012) (PubMed).
: "p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 6, Issue 3, pp. 423-31, (2011) (PubMed).
: "Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9067-76, (2010) (PubMed).
: "Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12935-47, (2010) (PubMed).
: "Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway." in: Cancer research, Vol. 70, Issue 18, pp. 7176-86, (2010) (PubMed).
: "The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair." in: DNA repair, Vol. 9, Issue 7, pp. 813-23, (2010) (PubMed).
: "Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5249-57, (2010) (PubMed).
: "BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells." in: Oncogene, Vol. 29, Issue 38, pp. 5274-85, (2010) (PubMed).
Synonyms and alternative names related to Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D
protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D), protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d), protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), protein phosphatase, Mg2+/Mn2+ dependent, 1Db (ppm1db), protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog (ppm1d.L), protein phosphatase, Mg2+/Mn2+ dependent, 1Da (ppm1da), AV338790, PP2C-DELTA, ppm1d, WIP1, Wip1, wu:fj44c08, zgc:55836, zgc:77316, zgc:103518Protein level used designations for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D
- protein phosphatase 1D
- protein phosphatase 1D magnesium-dependent, delta isoform
- protein phosphatase 2C delta isoform
- protein phosphatase Wip1
- wild-type p53-induced phosphatase 1
- PP2C-delta
- p53-induced protein phosphatase 1
- protein phosphatase 2C isoform delta
- protein phosphatase magnesium-dependent 1 delta
- protein phosphatase 1D magnesium-dependent, delta
- protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog
- protein phosphatase, Mg2+/Mn2+ dependent, 1D
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