Prosaposin 产品
(Prosaposin (PSAP))
Categories
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured Prosaposin Categories
Prosaposin 抗体
High quality antibodies with extensive validation data.
Prosaposin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Prosaposin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Prosaposin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA, FACS, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN1098150
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (10)
Cat. No.
ABIN7435130
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
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- (10)
Cat. No.
ABIN3022606
Quantity
100 μL
Datasheet
Datasheet
Recommended Prosaposin ELISA试剂盒
Product
Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958859
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Goat
Analytical Method
Competition ELISA
Validations
Cat. No.
ABIN994985
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN994986
Quantity
96 tests
Datasheet
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Recommended Prosaposin 蛋白
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Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
- (1)
Cat. No.
ABIN1316504
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124603
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316506
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Prosaposin Products
: "Putative Biomarkers for Malignant Pleural Mesothelioma Suggested by Proteomic Analysis of Cell Secretome." in: Cancer genomics & proteomics, Vol. 17, Issue 3, pp. 225-236, (2020) (PubMed).: "Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles." in: PeerJ, Vol. 7, pp. e8177, (2019) (PubMed).
: "Prosaposin is a regulator of progranulin levels and oligomerization. ..." in: Nature communications, Vol. 7, pp. 11992, (2016) (PubMed).
: "Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer." in: Breast cancer research : BCR, Vol. 17, Issue 1, pp. 123, (2015) (PubMed).
: "Decrease in prosaposin in spermatozoon is associated with polychlorinated biphenyl exposure." in: International journal of clinical and experimental pathology, Vol. 8, Issue 3, pp. 2436-48, (2015) (PubMed).
: "Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation." in: The Journal of biological chemistry, Vol. 289, Issue 29, pp. 20026-38, (2014) (PubMed).
: "Serum prosaposin levels are increased in patients with advanced prostate cancer." in: The Prostate, Vol. 72, Issue 3, pp. 253-69, (2012) (PubMed).
: "Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth." in: Cancer science, Vol. 103, Issue 10, pp. 1820-5, (2012) (PubMed).
: "The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." in: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).
Synonyms and alternative names related to Prosaposin
prosaposin (PSAP), prosaposin (Psap), prosaposin (psap), prosaposin (LOC100011417), prosaposin (LOC100304726), prosaposin (LOC100526719), surfactant protein A1 (SFTPA1), AI037048, cb759, GLBA, PSAP, PSP-A, SAP1, SFTPA1B, SGP-1, SGP1A, SP-A, wu:fa14a06, wu:fb36e02, wu:fb58g07Protein level used designations for Prosaposin
- proactivator polypeptide
- sphingolipid activator protein-1
- snoRNA MBII-198
- sulfated glycoprotein 1
- prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator)
- prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
- prosaposin
- proactivator polypeptide-like
- pulmonary surfactant-associated protein A
- surfactant protein A
- surfactant protein A1B
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