PRMT6 产品
(Protein Arginine Methyltransferase 6 (PRMT6))
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The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011].
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Featured PRMT6 Categories
Recommended PRMT6 抗体
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Reactivity
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Application
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- (5)
Cat. No.
ABIN949428
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
ABIN3032363
Quantity
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Reactivity
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Cat. No.
ABIN7165075
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Recommended PRMT6 ELISA试剂盒
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Analytical Method
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ABIN6951336
Quantity
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Recommended PRMT6 蛋白
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Cat. No.
ABIN7124643
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50 μg
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Wheat germ
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ABIN1316337
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10 μg
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Baculovirus
Validations
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Cat. No.
ABIN2669659
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Latest Publications for our PRMT6 Products
: "The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling." in: Cellular & molecular immunology, (2018) (PubMed).: "PRMT4 is involved in insulin secretion via the methylation of histone H3 in pancreatic β cells." in: Journal of molecular endocrinology, Vol. 54, Issue 3, pp. 315-24, (2015) (PubMed).
: "PELP1 oncogenic functions involve alternative splicing via PRMT6." in: Molecular oncology, Vol. 8, Issue 2, pp. 389-400, (2014) (PubMed).
: "A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator." in: Nucleic acids research, Vol. 42, Issue 13, pp. 8297-309, (2014) (PubMed).
: "Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor." in: Nucleic acids research, Vol. 40, Issue 19, pp. 9513-21, (2012) (PubMed).
: "Activity-based protein profiling of protein arginine methyltransferase 1." in: ACS chemical biology, Vol. 6, Issue 10, pp. 1127-35, (2011) (PubMed).
: "Regulation of post-translational protein arginine methylation during HeLa cell cycle." in: Biochimica et biophysica acta, Vol. 1800, Issue 9, pp. 977-85, (2010) (PubMed).
: "Proteomic identification and comparative analysis of asymmetrically arginine-methylated proteins in immortalized, young and senescent cells." in: Electrophoresis, Vol. 31, Issue 23-24, pp. 3823-33, (2010) (PubMed).
: "Arginine methylation regulates telomere length and stability." in: Molecular and cellular biology, Vol. 29, Issue 18, pp. 4918-34, (2009) (PubMed).
: "Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family." in: Journal of cell science, Vol. 122, Issue Pt 5, pp. 667-77, (2009) (PubMed).
Synonyms and alternative names related to PRMT6
Arginine methyltransferase 6 (Art6), protein arginine methyltransferase 6 (PRMT6), protein arginine methyltransferase 6 S homeolog (prmt6.S), arginine N-methyltransferase, type I (PRMT6), protein arginine methyltransferase 6 (prmt6), protein arginine methyltransferase 6 (Prmt6), protein arginine N-methyltransferase 6 (Prmt6), ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 6, ATPRMT6, AW124876, BB233495, CG9927, DART6, DKFZp459B1431, Dmel\\CG9927, HRMT1L6, Hrmt1l6, hrmt1l6, hrmt6, im:6908706, PRMT6, protein arginine methyltransferase 6Protein level used designations for PRMT6
- arginine methyltransferase 6
- CG9927-PA
- Art6-PA
- protein arginine methyltransferase 6
- HMT1 hnRNP methyltransferase-like 6
- Histone-arginine N-methyltransferase PRMT6
- protein arginine N-methyltransferase 6
- arginine N-methyltransferase, type I
- heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
- histone-arginine N-methyltransferase PRMT6
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