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PRMT5 蛋白

(Protein Arginine Methyltransferase 5 (PRMT5))
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).
PRMT5 Protein (AA 1-637) (GST tag) PRMT5 Protein (AA 1-637) (GST tag) PRMT5 Protein (AA 1-637) (GST tag) (ABIN1316333)

PRMT5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

PRMT5 Protein (AA 531-637) (GST tag) PRMT5 Protein (AA 531-637) (GST tag) PRMT5 Protein (AA 531-637) (GST tag) (ABIN1316335)

PRMT5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

PRMT5 Protein (DYKDDDDK Tag) PRMT5 Protein (DYKDDDDK Tag) PRMT5 Protein (DYKDDDDK Tag) (ABIN2669658)

PRMT5 宿主: 人 宿主: Baculovirus Recombinant EAA, ScA

PRMT5 蛋白 by Origin

Find PRMT5 蛋白 for a variety of species such as anti-Human PRMT5. The species listed below are among those available. Click on a link to go to the corresponding products.

PRMT5 蛋白 by Source

Here you will find PRMT5 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PRMT5 蛋白 by 蛋白类型

Here you can find PRMT5 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

PRMT5 蛋白 by 应用范围

Find PRMT5 蛋白 validated for a specific application such as WB, ELISA, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular PRMT5 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316333
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316335
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus
Validations
  • (2)
Cat. No. ABIN2669658
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3089077
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2729673
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
Cat. No. ABIN6700420
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our PRMT5 蛋白

Kanamaluru, Xiao, Fang, Choi, Kim, Veenstra, Kemper: "Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner." in: Molecular and cellular biology, Vol. 31, Issue 7, pp. 1540-50, (2011) (PubMed).

Aliases for PRMT5 蛋白

protein arginine methyltransferase 5 (PRMT5) 蛋白
protein arginine N-methyltransferase 5 (Prmt5) 蛋白
protein arginine methyltransferase 5 (Prmt5) 蛋白
protein arginine methyltransferase 5 (prmt5) 蛋白
protein arginine methyltransferase 5 L homeolog (prmt5.L) 蛋白
putative arginine N-methyltransferase, type II (PRMT5) 蛋白
Skb1 family protein (prmt5) 蛋白
protein arginine N-methyltransferase 5 (LOC100115766) 蛋白
Protein arginine N-methyltransferase 5 (prmt-5) 蛋白
DDBDRAFT_0187422 蛋白
DDBDRAFT_0235403 蛋白
DDB_0187422 蛋白
DDB_0235403 蛋白
HRMT1L5 蛋白
hrmt1l5 蛋白
hsl7 蛋白
IBP72 蛋白
ibp72 蛋白
JBP1 蛋白
Jbp1 蛋白
jbp1 蛋白
NV18830 蛋白
si:zc14a17.2 蛋白
SKB1 蛋白
Skb1 蛋白
skb1 蛋白
SKB1Hs 蛋白
skb1hs 蛋白
wu:fb95f10 蛋白
zgc:110669 蛋白
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