PRKAR2B 抗体
(Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].
recommended
recommended
PRKAR2B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
recommended
PRKAR2B 抗体 by 适用
Find PRKAR2B 抗体 for a variety of species such as anti-Human PRKAR2B, anti-Mouse PRKAR2B, anti-Rat PRKAR2B. The species listed below are among those available. Click on a link to go to the corresponding products.
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PRKAR2B 抗体 by 克隆形成能力
Find available monoclonal or polyclonal PRKAR2B 抗体. Click on a link to go to the corresponding products.
PRKAR2B 抗体 by 克隆
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PRKAR2B 抗体 by 标记
Find PRKAR2B 抗体 with a specific conjugate such as Biotin, APC, FITC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Cat. No.
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Quantity
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Application
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Quantity
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Datasheet
Datasheet
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Application
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, IF
Validations
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Human, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
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Quantity
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Datasheet
Datasheet
Latest Publications for our PRKAR2B 抗体
: "Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout." in: The Journal of comparative neurology, Vol. 521, Issue 5, pp. 1119-35, (2013) (PubMed).: "Bipolar cells of the ground squirrel retina." in: The Journal of comparative neurology, Vol. 519, Issue 4, pp. 759-74, (2011) (PubMed).
: "Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina." in: The Journal of comparative neurology, Vol. 519, Issue 3, pp. 433-50, (2011) (PubMed).
: "Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods." in: The Journal of comparative neurology, Vol. 507, Issue 1, pp. 1087-101, (2008) (PubMed).
: "Type 3a and type 3b OFF cone bipolar cells provide for the alternative rod pathway in the mouse retina." in: The Journal of comparative neurology, Vol. 502, Issue 6, pp. 1123-37, (2007) (PubMed).
: "Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7804-12, (2004) (PubMed).
: "Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 8, pp. 3044-51, (2002) (PubMed).
: "Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 21999-2002, (2001) (PubMed).
: "Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex." in: The Journal of clinical investigation, Vol. 106, Issue 5, pp. R31-8, (2000) (PubMed).
: "Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 23, pp. 10634-8, (1995) (PubMed).
Aliases for PRKAR2B 抗体
protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog (prkar2b.S) 抗体protein kinase cAMP-dependent type II regulatory subunit beta (PRKAR2B) 抗体
protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B) 抗体
protein kinase cAMP-dependent type II regulatory subunit beta (prkar2b) 抗体
protein kinase, cAMP dependent regulatory, type II beta (Prkar2b) 抗体
protein kinase cAMP-dependent type 2 regulatory subunit beta (Prkar2b) 抗体
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