PRKAR2B 产品
(Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
Categories
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].
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Featured PRKAR2B Categories
PRKAR2B 抗体
High quality antibodies with extensive validation data.
PRKAR2B ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PRKAR2B 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKAR2B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7269663
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN1848032
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7180071
Quantity
100 μL
Datasheet
Datasheet
Recommended PRKAR2B ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958935
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380428
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended PRKAR2B 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316253
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3133700
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2729602
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our PRKAR2B Products
: "Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells." in: Acta pharmacologica Sinica, Vol. 38, Issue 1, pp. 41-55, (2016) (PubMed).: "Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout." in: The Journal of comparative neurology, Vol. 521, Issue 5, pp. 1119-35, (2013) (PubMed).
: "Bipolar cells of the ground squirrel retina." in: The Journal of comparative neurology, Vol. 519, Issue 4, pp. 759-74, (2011) (PubMed).
: "Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina." in: The Journal of comparative neurology, Vol. 519, Issue 3, pp. 433-50, (2011) (PubMed).
: "Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop." in: The Journal of biological chemistry, Vol. 285, Issue 46, pp. 35910-8, (2010) (PubMed).
: "Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods." in: The Journal of comparative neurology, Vol. 507, Issue 1, pp. 1087-101, (2008) (PubMed).
: "Type 3a and type 3b OFF cone bipolar cells provide for the alternative rod pathway in the mouse retina." in: The Journal of comparative neurology, Vol. 502, Issue 6, pp. 1123-37, (2007) (PubMed).
: "Selective modulation of protein kinase A I and II reveals distinct roles in thyroid cell gene expression and growth." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 12, pp. 3196-211, (2006) (PubMed).
: "Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7804-12, (2004) (PubMed).
: "Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 8, pp. 3044-51, (2002) (PubMed).
Synonyms and alternative names related to PRKAR2B
protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog (prkar2b.S), protein kinase cAMP-dependent type II regulatory subunit beta (PRKAR2B), protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B), protein kinase cAMP-dependent type II regulatory subunit beta (prkar2b), protein kinase, cAMP dependent regulatory, type II beta (Prkar2b), protein kinase cAMP-dependent type 2 regulatory subunit beta (Prkar2b), AI451071, AW061005, MGC83177, Pkarb2, PKARIIbeta, PRKAR2, PRKAR2B, RATDNA, RII(beta), RII-BETAProtein level used designations for PRKAR2B
- protein kinase, cAMP-dependent, regulatory, type II, beta
- cAMP-dependent protein kinase, regulatory subunit beta 2
- cAMP-dependent protein kinase type II-beta regulatory subunit-like
- protein kinase, cAMP dependent regulatory, type II beta
- cAMP-dependent protein kinase type II-beta regulatory subunit
- Type II beta regulatory subunit of cAMP-dependent protein kinase
- H_RG363E19.2
- WUGSC:H_RG363E19.2
- cAMP-dependent protein kinase type II-beta regulatory chain
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