PRKAR2A 产品
(Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
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cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008].
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Featured PRKAR2A Categories
PRKAR2A 抗体
High quality antibodies with extensive validation data.
PRKAR2A 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKAR2A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN562376
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7146620
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN1513416
Quantity
100 μg
Datasheet
Datasheet
Recommended PRKAR2A 蛋白
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Reactivity
Source
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Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316249
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316251
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN5623689
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PRKAR2A Products
: "The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics." in: The Journal of cell biology, Vol. 202, Issue 3, pp. 453-62, (2013) (PubMed).: "Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C." in: BMC cell biology, Vol. 12, pp. 18, (2011) (PubMed).
: "Endosome-to-Golgi transport is regulated by protein kinase A type II alpha." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1991-7, (2003) (PubMed).
: "Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 5, pp. 2194-205, (2003) (PubMed).
: "Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14360-6, (2000) (PubMed).
Synonyms and alternative names related to PRKAR2A
protein kinase cAMP-dependent type II regulatory subunit alpha (PRKAR2A), protein kinase, cAMP-dependent, regulatory, type II, alpha, B (prkar2ab), protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A), protein kinase, cAMP dependent regulatory, type II alpha (Prkar2a), protein kinase cAMP-dependent type 2 regulatory subunit alpha (Prkar2a), protein kinase cAMP-dependent type II regulatory subunit alpha (Prkar2a), 1110061A24Rik, AI317181, AI836829, PKR2, PRKAR2, prkar2a, PRKAR2A, RII(alpha), zgc:85886Protein level used designations for PRKAR2A
- cAMP-dependent protein kinase regulatory subunit RII alpha
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- protein kinase A, RII-alpha subunit
- cAMP-dependent protein kinase, regulatory subunit alpha 2
- protein kinase, cAMP-dependent, regulatory, type II, alpha
- cAMP-dependent protein kinase type II-alpha regulatory subunit-like
- protein kinase cAMP-dependent regulatory type II alpha
- protein kinase, cAMP-dependent, regulatory, type 2, alpha
- LOW QUALITY PROTEIN: cAMP-dependent protein kinase type II-alpha regulatory subunit
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