PRKAR1A 抗体
(Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].
recommended
recommended
PRKAR1A 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
PRKAR1A 抗体 by 应用范围
Find PRKAR1A 抗体 validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.
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PRKAR1A 抗体 by 克隆形成能力
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PRKAR1A 抗体 by 标记
Find PRKAR1A 抗体 with a specific conjugate such as Biotin, APC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Cat. No.
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Quantity
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Datasheet
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Application
WB, ELISA, IHC, IF, ICC
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Cat. No.
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Quantity
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Datasheet
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Quantity
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Datasheet
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Application
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Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IF
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Cat. No.
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Quantity
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Datasheet
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Cat. No.
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Quantity
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Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus laevis, Zebrafish (Danio rerio)
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Cat. No.
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Quantity
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Datasheet
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Datasheet
Datasheet
Reactivity
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IF, IC
Validations
- (2)
Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Quantity
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Datasheet
Datasheet
Latest Publications for our PRKAR1A 抗体
: "Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion." in: Hepatology (Baltimore, Md.), Vol. 68, Issue 4, pp. 1441-1447, (2019) (PubMed).: "Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 6, pp. 607-15, (2018) (PubMed).
: "Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex." in: Scientific reports, Vol. 6, pp. 33557, (2016) (PubMed).
: "Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. 399-408, (2015) (PubMed).
: "PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors." in: The American journal of surgical pathology, Vol. 38, Issue 8, pp. 1079-87, (2014) (PubMed).
: "An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 190, Issue 1, pp. 51-61, (2014) (PubMed).
: "MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer." in: Molecular cancer, Vol. 13, pp. 239, (2014) (PubMed).
: "Rapid generation of a mouse model for Middle East respiratory syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 13, pp. 4970-5, (2014) (PubMed).
: "Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension." in: Science translational medicine, Vol. 5, Issue 200, pp. 200ra117, (2013) (PubMed).
: "Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1029-42, (2013) (PubMed).
Aliases for PRKAR1A 抗体
protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) 抗体protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a) 抗体
protein kinase cAMP-dependent type 1 regulatory subunit alpha (Prkar1a) 抗体
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa) 抗体
cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene (LOC707275) 抗体
protein kinase cAMP-dependent type I regulatory subunit alpha (Prkar1a) 抗体
protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog (prkar1a.S) 抗体
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