Presenilin 2 抗体
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].
recommended
PSEN2 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
recommended
recommended
Presenilin 2 抗体 by 应用范围
Find Presenilin 2 抗体 validated for a specific application such as WB, ELISA, IHC, IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
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Presenilin 2 抗体 by 克隆形成能力
Find available monoclonal or polyclonal Presenilin 2 抗体. Click on a link to go to the corresponding products.
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Popular Presenilin 2 抗体
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Cat. No.
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Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN3032302
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (3)
Cat. No.
ABIN7263725
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3044383
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2781802
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (4)
Cat. No.
ABIN7043554
Quantity
0.2 mL
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Datasheet
Reactivity
Human, Rat
Application
WB, IHC, IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN1493957
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN6736670
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IHC
Validations
- (2)
Cat. No.
ABIN634258
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, FACS
Validations
- (4)
- (2)
Cat. No.
ABIN1944732
Quantity
400 μL
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Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN7164268
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p), FACS
Validations
- (1)
Cat. No.
ABIN2577343
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p), IHC (p)
Validations
Cat. No.
ABIN704516
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
Cat. No.
ABIN704518
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN5009154
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN5009155
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our Presenilin 2 抗体
: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).
: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." in: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).
: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." in: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).
: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." in: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).
: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." in: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).
: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).
: "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 26, pp. 12180-4, (1996) (PubMed).
Aliases for Presenilin 2 抗体
presenilin 2 (PSEN2) 抗体presenilin 2 (Psen2) 抗体
presenilin 2 (psen2) 抗体
presenilin 2 S homeolog (psen2.S) 抗体
presenilin 2 (Alzheimer disease 4) (PSEN2) 抗体
trefoil factor 1 (Tff1) 抗体
AD3L 抗体
ad3l 抗体
AD4 抗体
ad4 抗体
Ad4h 抗体
ALG-3 抗体
Alg3 抗体
CMD1V 抗体
pre2 抗体
PS-2 抗体
PS2 抗体
ps2 抗体
Ps2 抗体
PSEN2 抗体
Psnl2 抗体
PSNL2 抗体
STM2 抗体
stm2 抗体
zf-PS2 抗体
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