Presenilin 2 产品
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Categories
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].
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Featured Presenilin 2 Categories
Presenilin 2 抗体
High quality antibodies with extensive validation data.
Presenilin 2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Presenilin 2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Presenilin 2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN3032302
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (3)
Cat. No.
ABIN7263725
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3044383
Quantity
100 μg
Datasheet
Datasheet
Recommended Presenilin 2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969496
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958724
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative
Validations
- (1)
Cat. No.
ABIN775490
Quantity
96 tests
Datasheet
Datasheet
Recommended Presenilin 2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316520
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7411894
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Monkey, Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2751153
Quantity
5 applications
Datasheet
Datasheet
Latest Publications for our Presenilin 2 Products
: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).
: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." in: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).
: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." in: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).
: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." in: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).
: "Increased expression of presenilin 2 inhibits protein synthesis." in: Molecular and cellular neurosciences, Vol. 19, Issue 1, pp. 111-24, (2002) (PubMed).
: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." in: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).
: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).
Synonyms and alternative names related to Presenilin 2
presenilin 2 (PSEN2), presenilin 2 (Psen2), presenilin 2 (psen2), presenilin 2 S homeolog (psen2.S), presenilin 2 (Alzheimer disease 4) (PSEN2), trefoil factor 1 (Tff1), AD3L, ad3l, AD4, ad4, Ad4h, ALG-3, Alg3, CMD1V, pre2, PS-2, PS2, ps2, Ps2, PSEN2, Psnl2, PSNL2, STM2, stm2, zf-PS2Protein level used designations for Presenilin 2
- AD3LP
- AD5
- E5-1
- PS-2
- STM-2
- presenilin-2
- PS-beta
- presenilin beta
- presenilin-beta
- presenilin 2 (Alzheimer disease 4)
- protein pS2
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