Presenilin 1 抗体
(Presenilin 1 (PSEN1))
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
recommended
recommended
PSEN1 适用: 人, 小鼠 WB, IHC (p), FACS, IF 宿主: 兔 Polyclonal RB2257 unconjugated
recommended
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Quantity
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Cat. No.
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Latest Publications for our Presenilin 1 抗体
: "Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy." in: Disease models & mechanisms, Vol. 12, Issue 12, (2020) (PubMed).: "Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin." in: PLoS ONE, Vol. 12, Issue 11, pp. e0188605, (2017) (PubMed).
: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).
: "Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 31, pp. 10674-85, (2012) (PubMed).
: "Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity." in: Cell death & disease, Vol. 3, pp. e389, (2012) (PubMed).
: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).
: "Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics." in: Molecular bioSystems, Vol. 6, Issue 9, pp. 1640-9, (2010) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).
: "Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease." in: Neurobiology of aging, Vol. 24, Issue 5, pp. 655-62, (2003) (PubMed).
Aliases for Presenilin 1 抗体
presenilin 1 (psen1) 抗体presenilin 1 (PSEN1) 抗体
presenilin 1 (Psen1) 抗体
presenilin 1 L homeolog (psen1.L) 抗体
ad3 抗体
AD3 抗体
Ad3h 抗体
fad 抗体
FAD 抗体
pre1 抗体
PS-1 抗体
ps1 抗体
PS1 抗体
psen 抗体
s182 抗体
S182 抗体
X-PS-alpha 抗体
X-PS-beta 抗体
zf-PS1 抗体
zfPS1 抗体
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