PRDM6 产品
(PR Domain Containing 6 (PRDM6))
Categories
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).
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Featured PRDM6 Categories
Recommended PRDM6 抗体
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Reactivity
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Cat. No.
Quantity
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Reactivity
Human
Application
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- (1)
Cat. No.
ABIN6739478
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
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Cat. No.
ABIN6146147
Quantity
100 μL
Datasheet
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Cat. No.
ABIN928519
Quantity
100 μL
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Datasheet
Recommended PRDM6 蛋白
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Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
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Cat. No.
ABIN3094724
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3135115
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PRDM6 Products
: "Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus." in: American journal of human genetics, Vol. 98, Issue 6, pp. 1082-91, (2016) (PubMed).Synonyms and alternative names related to PRDM6
PR/SET domain 6 (PRDM6), PR domain containing 6 (Prdm6), PR/SET domain 6 (Prdm6), putative histone-lysine N-methyltransferase PRDM6 (LOC100354345), PR domain containing 6 (prdm6), Gm92, PRDM6, PRISM, RGD1559594Protein level used designations for PRDM6
- PR domain zinc finger protein 6
- PR domain-containing protein 6
- PR-domain zinc finger protein 6
- putative histone-lysine N-methyltransferase PRDM6
- PR domain-containing protein in smooth muscle
- PR domain containing 6
- LOW QUALITY PROTEIN: putative histone-lysine N-methyltransferase PRDM6
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