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PPP1R12A ELISA试剂盒

(Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].

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PPP1R12A ELISA 试剂盒 (ABIN1380231)

PPP1R12A 适用: 人, 小鼠, 大鼠 pThr853 Colorimetric Cell ELISA Cell Culture Cells

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Popular PPP1R12A ELISA试剂盒

Product

Reactivity

Analytical Method

Validations

Cat. No.

Quantity

Datasheet

PPP1R12A ELISA 试剂盒

Reactivity Human, Mouse, Rat

Analytical Method Qualitative Cell ELISA

Validations

Cat. No. ABIN1380231

Quantity 2 x 96 tests

Datasheet Datasheet

Aliases for PPP1R12A ELISA试剂盒

protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) ELISA试剂盒
protein phosphatase 1 regulatory subunit 12A (PPP1R12A) ELISA试剂盒
protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) ELISA试剂盒
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