POT1 产品
(Protection of Telomeres 1 (POT1))
Categories
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
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Featured POT1 Categories
POT1 抗体
High quality antibodies with extensive validation data.
POT1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
POT1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POT1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7164998
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN565204
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN5663924
Quantity
100 μL
Datasheet
Datasheet
Recommended POT1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958904
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4972163
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5658187
Quantity
96 tests
Datasheet
Datasheet
Recommended POT1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315766
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
- (1)
Cat. No.
ABIN2729370
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409542
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our POT1 Products
: "Telomere protein RAP1 levels are affected by cellular aging and oxidative stress." in: Biomedical reports, Vol. 5, Issue 2, pp. 181-187, (2016) (PubMed).: "An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity." in: PLoS ONE, Vol. 11, Issue 5, pp. e0156378, (2016) (PubMed).
: "Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis." in: Frontiers in oncology, Vol. 5, pp. 257, (2015) (PubMed).
: "Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression." in: Aging cell, Vol. 14, Issue 3, pp. 391-9, (2015) (PubMed).
: "Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells." in: Oncotarget, Vol. 6, Issue 35, pp. 38079-92, (2015) (PubMed).
: "The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs." in: Biochimie, Vol. 115, pp. 17-27, (2015) (PubMed).
: "T-oligo as an anticancer agent in colorectal cancer." in: Biochemical and biophysical research communications, Vol. 446, Issue 2, pp. 596-601, (2014) (PubMed).
: "POT1 loss-of-function variants predispose to familial melanoma. ..." in: Nature genetics, Vol. 46, Issue 5, pp. 478-81, (2014) (PubMed).
: "Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response." in: Nucleic acids research, Vol. 41, Issue 2, pp. 900-11, (2013) (PubMed).
: "Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus." in: Oncogene, Vol. 32, Issue 49, pp. 5522-30, (2013) (PubMed).
Synonyms and alternative names related to POT1
protection of telomeres 1 (POT1), protection of telomeres 1 L homeolog (pot1.L), protection of telomeres 1A (Pot1a), protection of telomeres 1 (Pot1), 1500031H18Rik, AI851169, DKFZp469P1825, HPOT1, POT1, pot1, Pot1, Pot1aProtein level used designations for POT1
- POT1-like telomere end-binding protein
- protection of telomeres 1 homolog
- protection of telomeres protein 1
- POT1 protection of telomeres 1 homolog
- cPot1
- single-strand telomeric DNA-binding protein
- POT1 protection of telomeres 1 homolog (S. pombe)
- protection of telomeres 1
- protection of telomeres 1 homolog (S. pombe)
- protection of telomeres protein 1-like
- mPot1
- protection of telomeres 1A
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- Potassium Channel KAT3
- Potassium Channel Subfamily K Member 13
- Potassium Channel Tetramerisation Domain Containing 16
- Potassium Channel, Subfamily K, Member 5
- Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2
- Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 5
- POTEA
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- Potential Haloacid Dehalogenase-Like Hydrolase Similar To S. Cerevisiae UTR4 (YEL038W)
- POU Class 3 Homeobox 1
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