POMC 抗体
(Proopiomelanocortin (POMC))
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
recommended
recommended
recommended
POMC 适用: 人, 小鼠, 大鼠 ELISA, IHC, FACS, IF, Coat, StM 宿主: 小鼠 Monoclonal 57 unconjugated
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POMC 抗体 by 适用
Find POMC 抗体 for a variety of species such as anti-Human POMC, anti-Rat POMC, anti-Mouse POMC. The species listed below are among those available. Click on a link to go to the corresponding products.
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POMC 抗体 by 克隆形成能力
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Popular POMC 抗体
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
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Cat. No.
ABIN185387
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP
Validations
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Cat. No.
ABIN519039
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC, FACS, IF, Coat, StM
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- (4)
Cat. No.
ABIN6940336
Quantity
100 μg
Datasheet
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Reactivity
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Application
ELISA, ICC
Validations
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Cat. No.
ABIN5542293
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7242302
Quantity
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Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN519038
Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
ABIN3017231
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN5542292
Quantity
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Datasheet
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Reactivity
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Application
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IHC, ICC
Validations
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Cat. No.
ABIN1077682
Quantity
100 μL
Datasheet
Datasheet
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Application
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Validations
- (3)
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
- (2)
Cat. No.
ABIN519036
Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, StM
Validations
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Cat. No.
ABIN6940344
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC, Coat, StM
Validations
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Quantity
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Datasheet
Datasheet
Latest Publications for our POMC 抗体
: "A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 31, Issue 1-2, pp. 17-29, (2020) (PubMed).: "Hindbrain dorsal vagal complex AMPK controls hypothalamic gluco-regulatory transmitter and counter-regulatory hormone responses to hypoglycemia." in: Brain research bulletin, Vol. 144, pp. 171-179, (2019) (PubMed).
: "Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice." in: The Journal of biological chemistry, Vol. 294, Issue 13, pp. 4946-4955, (2019) (PubMed).
: "Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide." in: Neuroscience, Vol. 383, pp. 46-59, (2019) (PubMed).
: "Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity." in: The Journal of clinical investigation, Vol. 128, Issue 3, pp. 1125-1140, (2018) (PubMed).
: "Air-liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2." in: Cell death discovery, Vol. 3, pp. 17001, (2017) (PubMed).
: "A potential role for the secretogranin II-derived peptide EM66 in the hypothalamic regulation of feeding behaviour." in: Journal of neuroendocrinology, Vol. 29, Issue 3, (2017) (PubMed).
: "Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation." in: Neurochemical research, Vol. 41, Issue 9, pp. 2289-99, (2016) (PubMed).
: "Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury." in: Neural regeneration research, Vol. 7, Issue 22, pp. 1729-35, (2015) (PubMed).
: "Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain." in: PLoS ONE, Vol. 8, Issue 12, pp. e81563, (2013) (PubMed).
Aliases for POMC 抗体
proopiomelanocortin a (pomca) 抗体pro-opiomelanocortin-alpha (Pomc) 抗体
proopiomelanocortin (POMC) 抗体
proopiomelanocortin (Pomc) 抗体
ACTH 抗体
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Pomc1 抗体
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SI:bZ36D5.1 抗体
si:bz36d5.2 抗体
SI:bZ36D5.4 抗体
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