POLR2A/RPB1 产品
(RNA Polymerase II Subunit RPB1 (POLR2A))
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This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008].
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Featured POLR2A/RPB1 Categories
POLR2A/RPB1 抗体
High quality antibodies with extensive validation data.
POLR2A/RPB1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
POLR2A/RPB1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POLR2A/RPB1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7265278
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP, ChIP
Validations
- (5)
Cat. No.
ABIN6145914
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
Cat. No.
ABIN3022933
Quantity
100 μL
Datasheet
Datasheet
Recommended POLR2A/RPB1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380131
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended POLR2A/RPB1 蛋白
Latest Publications for our POLR2A/RPB1 Products
: "Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes." in: eLife, Vol. 7, (2019) (PubMed).: "Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome." in: Nucleic acids research, Vol. 47, Issue 1, pp. 122-133, (2019) (PubMed).
: "Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination." in: Molecular cell, Vol. 74, Issue 1, pp. 158-172.e9, (2019) (PubMed).
: "Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma." in: Therapeutic advances in medical oncology, Vol. 11, pp. 1758835919864850, (2019) (PubMed).
: "ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop." in: Molecular cell, (2019) (PubMed).
: "Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma." in: Oncotarget, Vol. 8, Issue 17, pp. 28696-28710, (2017) (PubMed).
: "PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia." in: Oncotarget, Vol. 7, Issue 6, pp. 6379-97, (2016) (PubMed).
: "Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation." in: Nucleic acids research, Vol. 42, Issue 22, pp. 13674-88, (2015) (PubMed).
: "Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing." in: Molecular and cellular biology, Vol. 34, Issue 13, pp. 2488-98, (2014) (PubMed).
: "Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction." in: Antimicrobial agents and chemotherapy, Vol. 57, Issue 3, pp. 1323-31, (2013) (PubMed).
Synonyms and alternative names related to POLR2A/RPB1
DNA-directed RNA polymerase II largest subunit (NCU02103), DNA-directed RNA polymerase II largest subunit (BBOV_I003360), DNA-directed RNA polymerase II subunit RPB1 (EDI_169920), DNA-directed RNA polymerase II subunit RPB1 (CMU_000800), RNA polymerase II large subunit Rpb1 (SJAG_01713), DNA-directed RNA polymerase II subunit RPB1 (MGYG_01527), RNA polymerase II subunit A (POLR2A), DNA-directed RNA polymerase II largest subunit (TP03_0185), DNA-directed RNA polymerase II largest subunit (EBI_22514), DNA-directed RNA polymerase II largest subunit, putative (CGB_E5020W), polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (POLR2A), RNA polymerase II subunit A (polr2a), polymerase (RNA) II (DNA directed) polypeptide A (Polr2a), RNA polymerase II subunit A (Polr2a), 19.m02399, 220kDa, hRPB220, hsRPB1, NCU02103.1, POLR2, POLR2A, POLRA, Rpb1, RPB1, RPBh1, RpIILS, RPO2, Rpo2-1, RPOL2Protein level used designations for POLR2A/RPB1
- DNA-directed RNA polymerase II subunit RPB1
- polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
- 220 kDa DNA-directed RNA polymerase polypeptide A
- DNA-directed RNA polymerase II largest subunit
- RNA polymerase II polypeptide A
- DNA-directed RNA polymerase II A
- DNA-directed RNA polymerase II subunit A
- DNA-directed RNA polymerase III largest subunit
- RNA polymerase II 1
- RNA polymerase II subunit B1
- Polymerase (RNA II (DNA directed), large polypeptide
- DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
- RNA-directed RNA polymerase II subunit RPB1
- polymerase (RNA) II (DNA directed) polypeptide A (220kD)
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