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POLH 产品

(Polymerase (DNA Directed), eta (POLH))

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This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].

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Featured POLH Categories

POLH 抗体

High quality antibodies with extensive validation data.

POLH 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended POLH 抗体

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Reactivity Human
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Cat. No. ABIN7150247
Quantity 100 μg
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Reactivity Human, Mouse
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Cat. No. ABIN7252888
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Cat. No. ABIN7259837
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Recommended POLH 蛋白

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Cat. No. ABIN1315646
Quantity 10 μg
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Reactivity Human
Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3094678
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Reactivity Mouse
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Cat. No. ABIN3137297
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Latest Publications for our POLH Products

Barkley, Palle, Durando, Day, Gurkar, Kakusho, Li, Masai, Vaziri: "c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks." in: Molecular biology of the cell, Vol. 23, Issue 10, pp. 1943-54, (2012) (PubMed).

Day, Palle, Barkley, Kakusho, Zou, Tateishi, Verreault, Masai, Vaziri: "Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication." in: The Journal of cell biology, Vol. 191, Issue 5, pp. 953-66, (2010) (PubMed).

Parker, Bielen, Dikic, Ulrich: "Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae." in: Nucleic acids research, Vol. 35, Issue 3, pp. 881-9, (2007) (PubMed).

Skoneczna, McIntyre, Skoneczny, Policinska, Sledziewska-Gojska: "Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae." in: Journal of molecular biology, Vol. 366, Issue 4, pp. 1074-86, (2007) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Glick, Vigna, Loeb: "Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions." in: The EMBO journal, Vol. 20, Issue 24, pp. 7303-12, (2001) (PubMed).

Yuasa, Masutani, Eki, Hanaoka: "Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene." in: Oncogene, Vol. 19, Issue 41, pp. 4721-8, (2000) (PubMed).

Masutani, Kusumoto, Yamada, Dohmae, Yokoi, Yuasa, Araki, Iwai, Takio, Hanaoka: "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta." in: Nature, Vol. 399, Issue 6737, pp. 700-4, (1999) (PubMed).

Johnson, Kondratick, Prakash, Prakash: "hRAD30 mutations in the variant form of xeroderma pigmentosum." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 263-5, (1999) (PubMed).

Synonyms and alternative names related to POLH

polymerase (DNA directed), eta S homeolog (polh.S), DNA polymerase eta (POLH), polymerase (DNA directed), eta (polh), DNA polymerase eta (Tb10.70.6190), putative DNA polymerase eta (LINJ_21_0690), polymerase (DNA directed), eta (Polh), DNA polymerase eta (LOC100443019), DNA polymerase eta (polh), DNA polymerase eta (Polh), polymerase (DNA directed), eta (RAD 30 related) (Polh), fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642

Protein level used designations for POLH

  • DNA-directed DNA polymerase eta
  • DNA polymerase eta
  • polymerase (DNA directed), eta
  • DNA polymerase eta-like
  • polymerase eta
  • RAD30 homolog A
  • xeroderma pigmentosum variant type protein
  • polymerase (DNA directed), eta (RAD 30 related)
  • xeroderma pigmentosum variant type protein homolog
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