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PNKP 产品

(Polynucleotide Kinase 3'-Phosphatase (PNKP))

Categories

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010].

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Featured PNKP Categories

PNKP 抗体

High quality antibodies with extensive validation data.

PNKP ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PNKP 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PNKP 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (1)
  • (8)
Cat. No. ABIN6145836
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN7262583
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (5)
Cat. No. ABIN564910
Quantity 50 μL
Datasheet Datasheet

Recommended PNKP ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1123845
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1123846
Quantity 96 tests
Datasheet Datasheet

Recommended PNKP 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315552
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315550
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3086075
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PNKP Products

Maertens, Kuzmickas, Manchester, Emerson, Gavin, Guild, Wong, De Raedt, Bowman-Colin, Hatchi, Garraway, Flaherty, Pathania, Elledge, Cichowski: "MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas." in: Cancer discovery, Vol. 9, Issue 4, pp. 526-545, (2019) (PubMed).

Yip, Keszei, Feng, Chu, McKenna, Shao: "Mechanism for recycling tRNAs on stalled ribosomes." in: Nature structural & molecular biology, Vol. 26, Issue 5, pp. 343-349, (2019) (PubMed).

Gao, Chakraborty, Geater, Pradhan, Gordon, Snowden, Yuan, Dickey, Choudhary, Ashizawa, Ellerby, La Spada, Thompson, Hazra, Sarkar: "Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription." in: eLife, Vol. 8, (2019) (PubMed).

Zagorac, Fernandez-Gaitero, Penning, Post, Bueno, Mouron, Manso, Morente, Alonso, Serra, Muñoz, Gómez-López, Lopez-Acosta, Jimenez-Renard, Gris-Oliver, Al-Shahrour, Piñeiro-Yañez, Montoya-Suarez et al.: "In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. ..." in: Nature communications, Vol. 9, Issue 1, pp. 3501, (2018) (PubMed).

Zhang, Sun, Ye, Ashraf, Chen, Zhu, He, Xu, Wei, Chen, Fu, Liu, Cao: "Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response." in: Journal of proteome research, Vol. 14, Issue 12, pp. 5157-68, (2016) (PubMed).

Markkanen, Fischer, Ledentcova, Kessler, Dianov: "Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability." in: Nucleic acids research, Vol. 43, Issue 7, pp. 3667-79, (2015) (PubMed).

Shimada, Dumitrache, Russell, McKinnon: "Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability." in: The EMBO journal, Vol. 34, Issue 19, pp. 2465-80, (2015) (PubMed).

Zolner, Abdou, Ye, Mani, Fanta, Yu, Douglas, Tahbaz, Fang, Dobbs, Wang, Morrice, Hendzel, Weinfeld, Lees-Miller: "Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage." in: Nucleic acids research, Vol. 39, Issue 21, pp. 9224-37, (2011) (PubMed).

Mani, Karimi-Busheri, Fanta, Cass, Weinfeld: "Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex." in: Biochemistry, Vol. 42, Issue 41, pp. 12077-84, (2003) (PubMed).

Chappell, Hanakahi, Karimi-Busheri, Weinfeld, West: "Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining." in: The EMBO journal, Vol. 21, Issue 11, pp. 2827-32, (2002) (PubMed).

Synonyms and alternative names related to PNKP

polynucleotide kinase 3'-phosphatase (PNKP), polynucleotide kinase 3'-phosphatase (Pnkp), polynucleotide kinase 3'-phosphatase (Tc00.1047053507017.50), polynucleotide kinase 3'-phosphatase (Tc00.1047053505807.190), polynucleotide kinase 3'-phosphatase (Tb927.6.1580), polynucleotide kinase 3'-phosphatase (BBOV_IV000690), polynucleotide kinase 3'-phosphatase (CC1G_05202), hypothetical protein (PGTG_20262), hypothetical protein (PGTG_18987), polynucleotide kinase 3'-phosphatase (pnkp.S), polynucleotide kinase 3'-phosphatase (pnkp), polynucleotide kinase 3'- phosphatase (Pnkp), 21.m03011, 1810009G08Rik, EIEE10, MCSZ, PNK, Tb06.28P18.320

Protein level used designations for PNKP

  • DNA 5'-kinase/3'-phosphatase
  • Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)
  • bifunctional polynucleotide phosphatase/kinase
  • polynucleotide kinase 3'-phosphatase
  • polynucleotide kinase-3'-phosphatase
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