PMS2 产品
(PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
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Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753}.
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Featured PMS2 Categories
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Latest Publications for our PMS2 Products
: "Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin." in: PLoS ONE, Vol. 16, Issue 1, pp. e0245581, (2021) (PubMed).: "A phase 2 study of temozolomide in pretreated metastatic colorectal cancer with MGMT promoter methylation." in: British journal of cancer, Vol. 116, Issue 10, pp. 1279-1286, (2017) (PubMed).
: "Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 3, pp. 972-80, (2004) (PubMed).
: "ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage." in: Molecular and cellular biology, Vol. 24, Issue 14, pp. 6430-44, (2004) (PubMed).
: "Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation." in: Cancer research, Vol. 64, Issue 14, pp. 4721-7, (2004) (PubMed).
: "Hereditary nonpolyposis colorectal cancer and related conditions." in: American journal of medical genetics. Part A, Vol. 122A, Issue 4, pp. 325-34, (2003) (PubMed).
: "Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair." in: Genes & development, Vol. 10, Issue 4, pp. 407-20, (1996) (PubMed).
: "It was a very good year for DNA repair." in: Cell, Vol. 76, Issue 1, pp. 1-4, (1994) (PubMed).
: "Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene." in: Molecular and cellular biology, Vol. 14, Issue 1, pp. 407-15, (1994) (PubMed).
: "MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast." in: Science (New York, N.Y.), Vol. 265, Issue 5175, pp. 1091-3, (1994) (PubMed).
Synonyms and alternative names related to PMS2
PMS1 homolog 2, mismatch repair system component (PMS2), PMS1 homolog 2, mismatch repair system component (Pms2), PMS1 homolog2, mismatch repair system component (Pms2), mismatch repair endonuclease PMS2 (LOC463257), mismatch repair endonuclease PMS2 (LOC107984056), AW555130, HNPCC4, PMS2CL, PMSL2, Pmsl2Protein level used designations for PMS2
- DNA mismatch repair protein PMS2
- H_DJ0042M02.9
- PMS1 protein homolog 2
- mismatch repair endonuclease PMS2
- PMS2 postmeiotic segregation increased 2
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