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PML 产品

(Promyelocytic Leukemia (PML))
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

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Featured PML Categories

PML 抗体

High quality antibodies with extensive validation data.

PML ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PML 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PML 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, ELISA, PLA
Validations
  • (6)
Cat. No. ABIN562289
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, ELISA, ICC
Validations
  • (1)
  • (4)
Cat. No. ABIN6264315
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ELISA, FACS
Validations
  • (6)
Cat. No. ABIN3032330
Quantity 0.4 mL
Datasheet Datasheet

Recommended PML ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (4)
Cat. No. ABIN6720583
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381443
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951212
Quantity 96 tests
Datasheet Datasheet

Recommended PML 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315516
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2729208
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396061
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PML Products

Missiroli, Perrone, Gafà, Nicoli, Bonora, Morciano, Boncompagni, Marchi, Lebiedzinska-Arciszewska, Vezzani, Lanza, Kricek, Borghi, Fiorica, Ito, Wieckowski, Di Virgilio, Abelli, Pinton, Giorgi: "PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment." in: Cell death and differentiation, pp. 1-13, (2022) (PubMed).

Chen, Ou Yang, Juang, Chen, Chen, Tsui, Chang, Tsai, Hsueh, Liao: "Proteomic characterization of arsenic and cadmium exposure in bladder cells." in: Rapid communications in mass spectrometry : RCM, (2019) (PubMed).

Wu, Shao, Zhou, Sun, Wang, Yan, Liu, Wu, Ye, Huang, Zhou et al.: "Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Rarα Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: in Vitro and in Vivo ..." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 48, Issue 6, pp. 2286-2301, (2018) (PubMed).

Li, Zhong, Liu, Yu, Chen, Wang, Shi, Yuan: "Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition." in: Cancer research, Vol. 78, Issue 1, pp. 230-245, (2018) (PubMed).

Lång, Eriksson, Schink, Lång, Blicher, Połeć, Brech, Dalhus, Bøe: "Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites." in: Nucleus (Austin, Tex.), Vol. 8, Issue 4, pp. 404-420, (2018) (PubMed).

Niu, Livingston, Li, Beran, Daffis, Ramakrishnan, Burdette, Peiser, Salas, Ramos, Yu, Cheng, Strubin, Delaney Iv, Fletcher: "The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169648, (2017) (PubMed).

Berscheminski, Brun, Speiseder, Wimmer, Ip, Terzic, Dobner, Schreiner: "Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation." in: Oncogene, Vol. 35, Issue 24, pp. 3178-89, (2016) (PubMed).

Komatsu, Nagata, Wodrich: "An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies." in: Journal of virology, Vol. 90, Issue 3, pp. 1657-67, (2016) (PubMed).

Yao, Wu, Chen, Zhang, Chen, Zhang: "The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162832, (2016) (PubMed).

Wimmer, Berscheminski, Blanchette, Groitl, Branton, Hay, Dobner, Schreiner: "PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53." in: Oncogene, Vol. 35, Issue 1, pp. 69-82, (2016) (PubMed).

Synonyms and alternative names related to PML

promyelocytic leukemia (PML), promyelocytic leukemia (Pml), 1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, TRIM19, Trim19

Protein level used designations for PML

  • RING finger protein 71
  • probable transcription factor PML
  • promyelocytic leukemia protein
  • promyelocytic leukemia, inducer of
  • protein PML
  • tripartite motif protein TRIM19
  • tripartite motif-containing protein 19
  • promyelocytic leukemia
  • probable transcription factor PML-like
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