PML 产品
(Promyelocytic Leukemia (PML))
Categories
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured PML Categories
PML 抗体
High quality antibodies with extensive validation data.
PML ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PML 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PML 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, ELISA, PLA
Validations
- (6)
Cat. No.
ABIN562289
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, ELISA, ICC
Validations
- (1)
- (4)
Cat. No.
ABIN6264315
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ELISA, FACS
Validations
- (6)
Cat. No.
ABIN3032330
Quantity
0.4 mL
Datasheet
Datasheet
Recommended PML ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
Cat. No.
ABIN6720583
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381443
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951212
Quantity
96 tests
Datasheet
Datasheet
Recommended PML 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315516
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2729208
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396061
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PML Products
: "PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment." in: Cell death and differentiation, pp. 1-13, (2022) (PubMed).: "Proteomic characterization of arsenic and cadmium exposure in bladder cells." in: Rapid communications in mass spectrometry : RCM, (2019) (PubMed).
: "Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Rarα Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: in Vitro and in Vivo ..." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 48, Issue 6, pp. 2286-2301, (2018) (PubMed).
: "Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition." in: Cancer research, Vol. 78, Issue 1, pp. 230-245, (2018) (PubMed).
: "Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites." in: Nucleus (Austin, Tex.), Vol. 8, Issue 4, pp. 404-420, (2018) (PubMed).
: "The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169648, (2017) (PubMed).
: "Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation." in: Oncogene, Vol. 35, Issue 24, pp. 3178-89, (2016) (PubMed).
: "An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies." in: Journal of virology, Vol. 90, Issue 3, pp. 1657-67, (2016) (PubMed).
: "The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162832, (2016) (PubMed).
: "PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53." in: Oncogene, Vol. 35, Issue 1, pp. 69-82, (2016) (PubMed).
Synonyms and alternative names related to PML
promyelocytic leukemia (PML), promyelocytic leukemia (Pml), 1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, TRIM19, Trim19Protein level used designations for PML
- RING finger protein 71
- probable transcription factor PML
- promyelocytic leukemia protein
- promyelocytic leukemia, inducer of
- protein PML
- tripartite motif protein TRIM19
- tripartite motif-containing protein 19
- promyelocytic leukemia
- probable transcription factor PML-like
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