PLAUR 产品
(Plasminogen Activator, Urokinase Receptor (PLAUR))
Categories
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008].
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Featured PLAUR Categories
PLAUR 抗体
High quality antibodies with extensive validation data.
PLAUR ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PLAUR 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PLAUR 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7431179
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IF (cc)
Validations
- (5)
Cat. No.
ABIN675443
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN7193215
Quantity
100 μL
Datasheet
Datasheet
Recommended PLAUR ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
- (1)
Cat. No.
ABIN6958616
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958617
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969366
Quantity
96 tests
Datasheet
Datasheet
Recommended PLAUR 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7275406
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275402
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275407
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PLAUR Products
: "uPAR isoform 2 forms a dimer and induces severe kidney disease in mice." in: The Journal of clinical investigation, Vol. 130, (2019) (PubMed).: "Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease." in: Nature medicine, Vol. 23, Issue 1, pp. 100-106, (2017) (PubMed).
: "Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion." in: BMC cancer, Vol. 17, Issue 1, pp. 350, (2017) (PubMed).
: "Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System." in: The Journal of biological chemistry, Vol. 292, Issue 7, pp. 2741-2753, (2017) (PubMed).
: "Clinical value of soluble urokinase-type plasminogen activator receptor in the diagnosis, prognosis, and therapeutic guidance of sepsis." in: The American journal of emergency medicine, Vol. 34, Issue 3, pp. 375-80, (2016) (PubMed).
: "Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. ..." in: Nature communications, Vol. 7, pp. 11626, (2016) (PubMed).
: "A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease." in: Kidney international, Vol. 87, Issue 3, pp. 564-74, (2015) (PubMed).
: "Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes." in: PLoS ONE, Vol. 9, Issue 8, pp. e105929, (2015) (PubMed).
: "uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells." in: Stem cell research, Vol. 12, Issue 3, pp. 716-29, (2014) (PubMed).
: "Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures." in: Biophysical journal, Vol. 107, Issue 9, pp. 2101-11, (2014) (PubMed).
Synonyms and alternative names related to PLAUR
plasminogen activator, urokinase receptor (Plaur), plasminogen activator, urokinase receptor (PLAUR), Cd87, CD87, Par, PLAUR, Plaur3, u-PAR, U-PAR, uPAR, UPAR, uPAR-2, uPAR-3, URKRProtein level used designations for PLAUR
- urokinase plasminogen activator receptor
- urokinase plasminogen activator surface receptor
- urokinase-type plasminogen activator receptor
- monocyte activation antigen Mo3
- u-plasminogen activator receptor form 2
- urokinase-type plasminogen activator (uPA) receptor
- U-PAR
- plasminogen activator urokinase receptor 3
- urinary plasminogen activator receptor 2
- urinary plasminogen activator receptor 3
- uPAR
- plasminogen activator, urokinase receptor
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