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PLAU 产品

(Plasminogen Activator, Urokinase (PLAU))
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

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Featured PLAU Categories

PLAU 抗体

High quality antibodies with extensive validation data.

PLAU ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PLAU 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PLAU 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, FACS, IHC (p)
Validations
  • (8)
  • (4)
Cat. No. ABIN1882148
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (5)
Cat. No. ABIN185470
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, IF
Validations
  • (6)
Cat. No. ABIN3032244
Quantity 0.4 mL
Datasheet Datasheet

Recommended PLAU ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (8)
  • (1)
Cat. No. ABIN6958612
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958613
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6976235
Quantity 96 tests
Datasheet Datasheet

Recommended PLAU 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7275455
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275453
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275460
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PLAU Products

Dreymann, Sabrowski, Danso, Menger: "Aptamer-Based Sandwich Assay Formats for Detection and Discrimination of Human High- and Low-Molecular-Weight uPA for Cancer Prognosis and Diagnosis." in: Cancers, Vol. 14, Issue 21, (2022) (PubMed).

Tian, Chen, Zhang, Li, Wang, Han, Zhang, Fu, Li, Nie, Zhao, Tan, Wang, Guan, Hong: "Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma." in: Oncotarget, Vol. 8, Issue 26, pp. 42300-42313, (2018) (PubMed).

Jia, Thelwell, Dilger, Bird, Daniels, Wadhwa: "Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy." in: Thrombosis research, Vol. 163, pp. 105-116, (2018) (PubMed).

Wang, Jiang, An, Mao, Lin, Sun: "Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro." in: Molecular medicine reports, Vol. 17, Issue 3, pp. 4273-4280, (2018) (PubMed).

Joseph, Tholanikunnel, Kaplan: "Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema." in: The Journal of allergy and clinical immunology, Vol. 140, Issue 1, pp. 170-176, (2017) (PubMed).

Liu, Zheng, Zhang, Wang, Yang, Bai, Dai: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." in: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).

Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

Shen, Chen, Gan, Hu, Zhong, Li, Xie, Liu, Li, Xu, Huang, Chen: "Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC." in: Biochemical and biophysical research communications, Vol. 470, Issue 3, pp. 627-34, (2016) (PubMed).

Huang, Liu, Huang, Li, Gan, Shen: "1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway." in: International journal of oncology, Vol. 48, Issue 3, pp. 1271-9, (2016) (PubMed).

Bi, Zeng, Zhao, Wei, Yu, Wang, Yu, Cao, Shan, Wei: "miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα." in: Molecular therapy. Nucleic acids, Vol. 5, Issue 9, pp. e368, (2016) (PubMed).

Synonyms and alternative names related to PLAU

plasminogen activator, urokinase (PLAU), urokinase-type plasminogen activator (CpipJ_CPIJ002131), urokinase-type plasminogen activator (CpipJ_CPIJ006543), urokinase-type plasminogen activator (CpipJ_CPIJ013396), urokinase-type plasminogen activator (CpipJ_CPIJ013623), plasminogen activator, urokinase (Plau), ATF, BDPLT5, PLAU, QPD, u-PA, UPA, uPA, UPAM, URK

Protein level used designations for PLAU

  • urokinase-type plasminogen activator
  • U-plasminogen activator
  • uPA
  • plasminogen activator, urokinase
  • plasminogen activator, urinary
  • Urinary plasminogen activator, urokinase
  • urokinase plasminogen activator preproprotein
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