PKM2 产品
(Pyruvate Kinase M2 (PKM2))
Categories
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].
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Featured PKM2 Categories
PKM2 抗体
High quality antibodies with extensive validation data.
PKM2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PKM2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PKM2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (10)
Cat. No.
ABIN7438913
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (13)
Cat. No.
ABIN7432133
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (5)
Cat. No.
ABIN744773
Quantity
100 μL
Datasheet
Datasheet
Recommended PKM2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (6)
Cat. No.
ABIN6574169
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960739
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960740
Quantity
96 tests
Datasheet
Datasheet
Recommended PKM2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315230
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315227
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124724
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our PKM2 Products
: "Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway." in: Cell reports, Vol. 30, Issue 6, pp. 1780-1797.e6, (2020) (PubMed).: "A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein." in: PLoS pathogens, Vol. 14, Issue 8, pp. e1007259, (2019) (PubMed).
: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).
: "PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer." in: Scientific reports, Vol. 7, Issue 1, pp. 2886, (2018) (PubMed).
: "Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis." in: Oncotarget, Vol. 9, Issue 25, pp. 17430-17442, (2018) (PubMed).
: "A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells." in: International journal of molecular sciences, Vol. 18, Issue 1, (2017) (PubMed).
: "MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells." in: Oncotarget, Vol. 8, Issue 20, pp. 33064-33077, (2017) (PubMed).
: "Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317695962, (2017) (PubMed).
: "Enhanced aerobic glycolysis of nasopharyngeal carcinoma cells by Epstein-Barr virus latent membrane protein 1." in: Experimental cell research, Vol. 359, Issue 1, pp. 94-100, (2017) (PubMed).
: "M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh's ESCC and promotes proliferation and migration of ESCC cells." in: Tumour biology, Vol. 37, Issue 2, pp. 2665-72, (2016) (PubMed).
Synonyms and alternative names related to PKM2
pyruvate kinase M1/2 (PKM), pyruvate kinase, muscle (Pkm), pyruvate kinase, muscle (PKM), AA414905, AL024370, AL024424, CTHBP, OIP3, Pk-2, Pk-3, PK3, Pk3, PKM, PKM2, Pkm2, PKM12, TCB, THBP1Protein level used designations for PKM2
- OIP-3
- OPA-interacting protein 3
- PK, muscle type
- cytosolic thyroid hormone-binding protein
- p58
- pyruvate kinase 2/3
- pyruvate kinase PKM
- pyruvate kinase isozymes M1/M2
- pyruvate kinase muscle isozyme
- thyroid hormone-binding protein 1
- thyroid hormone-binding protein, cytosolic
- tumor M2-PK
- pyruvate kinase 3
- ATP:pyruvate 2-o-phosphotransferase
- Pyruvate kinase isozymes M1/M2
- Pyruvate kinase muscle isozyme
- Pyruvate kinase PKM
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