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PKD1 蛋白

(Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].

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PKD1 Protein (AA 177-359) (His tag) (ABIN7505263)

PKD1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.

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PKD1 蛋白 by Source

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PKD1 蛋白 by 蛋白类型

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Popular PKD1 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

PKD1 Protein (AA 177-359) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7505263

Quantity 100 μg

Datasheet Datasheet

Aliases for PKD1 蛋白

polycystin 1, transient receptor potential channel interacting (PKD1) 蛋白
polycystin 1, transient receptor poteintial channel interacting (Pkd1) 蛋白
polycystin 1, transient receptor potential channel interacting (Pkd1) 蛋白
polycystin-1 (LOC749291) 蛋白
mFLJ00285 蛋白
PBP 蛋白
Pc-1 蛋白
PC1 蛋白
TRPP1 蛋白

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