PKC iota 产品
(Protein Kinase C, iota (PRKCI))
Categories
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008].
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Featured PKC iota Categories
PKC iota 抗体
High quality antibodies with extensive validation data.
PKC iota ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PKC iota 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PKC iota 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
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- (6)
Cat. No.
ABIN7444109
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (5)
Cat. No.
ABIN562391
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
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Cat. No.
ABIN3043909
Quantity
100 μg
Datasheet
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Recommended PKC iota ELISA试剂盒
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Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1116783
Quantity
96 tests
Datasheet
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Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1116784
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1057780
Quantity
96 tests
Datasheet
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Recommended PKC iota 蛋白
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Reactivity
Source
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Reactivity
Human
Source
Wheat germ
Validations
- (2)
Cat. No.
ABIN1316270
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316272
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509106
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PKC iota Products
: "PKCiota promotes ovarian tumor progression through deregulation of cyclin E." in: Oncogene, Vol. 35, Issue 19, pp. 2428-40, (2016) (PubMed).: "PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling." in: Biochemical and biophysical research communications, Vol. 470, Issue 2, pp. 306-12, (2016) (PubMed).
: "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 308, Issue 9, pp. G745-56, (2015) (PubMed).
: "Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells." in: Biology open, Vol. 2, Issue 11, pp. 1264-9, (2013) (PubMed).
: "Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma." in: The Journal of surgical research, Vol. 154, Issue 1, pp. 143-9, (2009) (PubMed).
: "Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 1, pp. 70-5, (2008) (PubMed).
: "Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 644-54, (2008) (PubMed).
: "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota." in: Cancer research, Vol. 68, Issue 18, pp. 7403-8, (2008) (PubMed).
: "Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms." in: The Journal of biological chemistry, Vol. 281, Issue 44, pp. 33773-88, (2006) (PubMed).
: "Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22118-23, (2004) (PubMed).
Synonyms and alternative names related to PKC iota
protein kinase C iota (PRKCI), protein kinase C, iota (prkci), protein kinase C, iota (Prkci), protein kinase C iota (Prkci), 2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkci, Pkcl, PKClambda, PRKCI, PrkclProtein level used designations for PKC iota
- PRKC-lambda/iota
- aPKC-lambda/iota
- atypical protein kinase C-lambda/iota
- protein kinase C iota type
- heart and soul protein
- nPKC-iota
- protein kinase C, iota
- protein kinase C iota
- protein kinase C, lambda
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