PIP5K1A 产品
(Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
Categories
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
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Featured PIP5K1A Categories
PIP5K1A 抗体
High quality antibodies with extensive validation data.
PIP5K1A 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PIP5K1A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN948678
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7163185
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (2)
Cat. No.
ABIN6264231
Quantity
100 μL
Datasheet
Datasheet
Recommended PIP5K1A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6220514
Quantity
96 tests
Datasheet
Datasheet
Recommended PIP5K1A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315137
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315135
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509093
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PIP5K1A Products
: "Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module." in: Nature immunology, Vol. 10, Issue 2, pp. 185-94, (2009) (PubMed).: "Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice." in: Brain research. Molecular brain research, Vol. 134, Issue 2, pp. 239-55, (2005) (PubMed).
: "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling." in: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 23036-45, (2003) (PubMed).
: "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 88, Issue 3-4, pp. 197-9, (2000) (PubMed).
Synonyms and alternative names related to PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A), phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa), phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab), im:7140933, PIP5K1A, pip5k1a, Pip5k1b, pip5k1b, pip5k1c, Pipk5a, Pipk5b, zgc:110576, zgc:158838Protein level used designations for PIP5K1A
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
- PIP5K1-alpha
- PIP5KIalpha
- phosphatidylinositol 4-phosphate 5-kinase type I alpha
- phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- ptdIns(4)P-5-kinase 1 alpha
- phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
- PI4P5K-I[a]
- PI4P5KIbeta
- phosphatidylinositol 4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type I alpha
- phosphatidylinositol-4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
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