PIK3R5 产品
(Phosphoinositide-3-Kinase, Regulatory Subunit 5 (PIK3R5))
Categories
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011].
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Featured PIK3R5 Categories
Recommended PIK3R5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN1500211
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN1500212
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (4)
Cat. No.
ABIN2786003
Quantity
100 μL
Datasheet
Datasheet
Recommended PIK3R5 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315090
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505214
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094632
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PIK3R5 Products
: "Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer." in: Cancer research and treatment : official journal of Korean Cancer Association, (2018) (PubMed).: "A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia." in: Human mutation, Vol. 33, Issue 2, pp. 351-4, (2012) (PubMed).
: "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma." in: The Journal of cell biology, Vol. 160, Issue 1, pp. 89-99, (2003) (PubMed).
: "Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 762-70, (1996) (PubMed).
: "Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin." in: Nature, Vol. 372, Issue 6506, pp. 570-3, (1995) (PubMed).
: "p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest." in: Genes & development, Vol. 8, Issue 1, pp. 9-22, (1994) (PubMed).
Synonyms and alternative names related to PIK3R5
phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), phosphoinositide-3-kinase regulatory subunit 5 S homeolog (pik3r5.S), phosphoinositide-3-kinase, regulatory subunit 5 (Pik3r5), phosphoinositide-3-kinase regulatory subunit 5 (Pik3r5), AV230647, F730038I15Rik, FOAP-2, p101, P101, P101-PI3K, RGD1563261Protein level used designations for PIK3R5
- PI3-kinase regulatory subunit 5
- phosphoinositide-3-kinase, regulatory subunit 5, p101
- PI3-kinase p101 subunit
- phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
- phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit
- phosphoinositide 3-kinase regulatory subunit 5
- protein FOAP-2
- ptdIns-3-kinase p101
- Phosphoinositide 3-kinase regulatory subunit 5
- IB PI3-kinase p101 subunit
- p101-PI3K
- ptdIns-3-kinase regulatory subunit
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