PIK3C2B 产品
(Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta (PIK3C2B))
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The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008].
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Featured PIK3C2B Categories
PIK3C2B 抗体
High quality antibodies with extensive validation data.
PIK3C2B 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PIK3C2B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (8)
Cat. No.
ABIN1500199
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN518887
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p), IF
Validations
- (4)
Cat. No.
ABIN1500198
Quantity
100 μL
Datasheet
Datasheet
Recommended PIK3C2B 蛋白
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315065
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405546
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2728944
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our PIK3C2B Products
: "PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets." in: Molecular metabolism, Vol. 5, Issue 7, pp. 459-71, (2016) (PubMed).: "Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia." in: Journal of veterinary internal medicine, Vol. 29, Issue 5, pp. 1387-94, (2016) (PubMed).
: "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity." in: The Journal of biological chemistry, Vol. 273, Issue 49, pp. 33082-90, (1999) (PubMed).
Synonyms and alternative names related to PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (Pik3c2b), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B), C2-PI3KProtein level used designations for PIK3C2B
- nuclear cap binding protein subunit 2
- phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
- phosphoinositide-3-kinase, class 2, beta polypeptide
- PI3K-C2-beta
- PI3K-C2beta
- PTDINS-3-kinase C2 beta
- phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide
- phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- phosphoinositide 3-kinase-C2-beta
- ptdIns-3-kinase C2 subunit beta
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