PIK3C2A 产品
(Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
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The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].
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Featured PIK3C2A Categories
PIK3C2A 抗体
High quality antibodies with extensive validation data.
PIK3C2A ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PIK3C2A 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PIK3C2A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7431707
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (4)
Cat. No.
ABIN518885
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (3)
Cat. No.
ABIN185194
Quantity
100 μg
Datasheet
Datasheet
Recommended PIK3C2A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958551
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
Cat. No.
ABIN1116456
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN2851450
Quantity
96 tests
Datasheet
Datasheet
Recommended PIK3C2A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315063
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509086
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7410745
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PIK3C2A Products
: "Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function. ..." in: Cancer cell, Vol. 32, Issue 4, pp. 444-459.e7, (2017) (PubMed).: "miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 1, pp. 291-6, (2014) (PubMed).
: "PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN." in: The Journal of clinical endocrinology and metabolism, Vol. 99, Issue 9, pp. 3363-72, (2014) (PubMed).
: "The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment." in: EMBO reports, Vol. 11, Issue 6, pp. 473-8, (2010) (PubMed).
: "Phosphoinositide 3-kinase C2alpha is activated upon smooth muscle cell migration and regulated by alpha(v)beta(3) integrin engagement." in: Biochemical and biophysical research communications, Vol. 297, Issue 2, pp. 261-6, (2002) (PubMed).
: "The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11943-50, (2000) (PubMed).
: "Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain." in: The Journal of biological chemistry, Vol. 271, Issue 23, pp. 13892-9, (1996) (PubMed).
Synonyms and alternative names related to PIK3C2A
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (PIK3C2A), phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha (Pik3c2a), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (pik3c2a), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha S homeolog (pik3c2a.S), phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (LOC100548137), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (Pik3c2a), phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha (pik3c2a), CPK, cpk, Cpk-m, PI3-K-C2(ALPHA), PI3-K-C2A, pi3-k-c2a, PI3KC2, sb:cb156, si:dkey-24l11.7, wu:fc02a04Protein level used designations for PIK3C2A
- C2-containing phosphatidylinositol kinase
- PI3K-C2-alpha
- PI3K-C2alpha
- phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
- phosphoinositide 3-kinase-C2-alpha
- phosphoinositide-3-kinase, class 2, alpha polypeptide
- ptdIns-3-kinase C2 subunit alpha
- phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
- phosphoinositide-3-kinase, class 2 alpha polypeptide
- pi3-k-c2(alpha)
- Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
- p170
- LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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