Phosphatidylinositol Binding clathrin Assembly Protein 产品
(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
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This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
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Featured Phosphatidylinositol Binding clathrin Assembly Protein Categories
Phosphatidylinositol Binding clathrin Assembly Protein 抗体
High quality antibodies with extensive validation data.
Phosphatidylinositol Binding clathrin Assembly Protein ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Phosphatidylinositol Binding clathrin Assembly Protein 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Phosphatidylinositol Binding clathrin Assembly Protein 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7163230
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN1501903
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (1)
Cat. No.
ABIN1385889
Quantity
100 μL
Datasheet
Datasheet
Recommended Phosphatidylinositol Binding clathrin Assembly Protein ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958523
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5657760
Quantity
96 tests
Datasheet
Datasheet
Recommended Phosphatidylinositol Binding clathrin Assembly Protein 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1315001
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2728884
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7408408
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Phosphatidylinositol Binding clathrin Assembly Protein Products
: "Cellular protein profiles altered by PRRSV infection of porcine monocytes-derived dendritic cells." in: Veterinary microbiology, Vol. 228, pp. 134-142, (2019) (PubMed).: "Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice." in: Journal of biomedical science, Vol. 23, Issue 1, pp. 49, (2016) (PubMed).
: "Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease." in: BMC neuroscience, Vol. 17, Issue 1, pp. 50, (2016) (PubMed).
: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).
: "Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis." in: PLoS ONE, Vol. 10, Issue 6, pp. e0129776, (2015) (PubMed).
: "Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 150-60, (2014) (PubMed).
: "Distribution and expression of picalm in Alzheimer disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 10, pp. 1071-7, (2010) (PubMed).
Synonyms and alternative names related to Phosphatidylinositol Binding clathrin Assembly Protein
leucine aminopeptidase 3 (LAP3), phosphatidylinositol binding clathrin assembly protein (PICALM), phosphatidylinositol binding clathrin assembly protein (Picalm), si:ch211-200p22.4 (si:ch211-200p22.4), CALM, Calm, CLTH, fit-1, fit1, LAP, LAP-3, mKIAA4114, PAP180, PEPSProtein level used designations for Phosphatidylinositol Binding clathrin Assembly Protein
- LAP
- cytosol aminopeptidase
- leucyl aminopeptidase
- peptidase S
- proline aminopeptidase
- prolyl aminopeptidase
- clathrin assembly lymphoid myeloid leukemia protein
- phosphatidylinositol-binding clathrin assembly protein
- clathrin assembly lymphoid myeloid leukemia
- clathrin-assembly lymphoid leukemia protein
- clathrin-assembly lymphoid myeloid leukemia protein
- rCALM
- uncharacterized protein LOC772071
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