PIAS4 抗体
(Protein Inhibitor of Activated STAT, 4 (PIAS4))
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.
recommended
PIAS4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
recommended
PIAS4 抗体 by 应用范围
Find PIAS4 抗体 validated for a specific application such as WB, ELISA, IHC, IHC (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
PIAS4 抗体 by 抗体来源
Find PIAS4 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
PIAS4 抗体 by 克隆形成能力
Find available monoclonal or polyclonal PIAS4 抗体. Click on a link to go to the corresponding products.
PIAS4 抗体 by 克隆
Find PIAS4 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
PIAS4 抗体 by 标记
Find PIAS4 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular PIAS4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6264199
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (2)
Cat. No.
ABIN388061
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7150970
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN1327475
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB, ICC
Validations
- (1)
Cat. No.
ABIN208255
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Xenopus laevis, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
Cat. No.
ABIN6735818
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6145602
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN388062
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN2777708
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN1533435
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN356771
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN356770
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
Cat. No.
ABIN7185417
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
Cat. No.
ABIN6286386
Quantity
50 μL
Datasheet
Datasheet
Latest Publications for our PIAS4 抗体
: "SUMOylation proteins in breast cancer." in: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).: "Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage." in: Journal of cell science, Vol. 126, Issue Pt 22, pp. 5284-92, (2013) (PubMed).
: "DNA ploidy cytometry testing for cervical cancer screening in China (DNACIC Trial): a prospective randomized, controlled trial." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 20, pp. 6438-45, (2009) (PubMed).
: "Developmental control of sumoylation pathway proteins in mouse male germ cells." in: Developmental biology, Vol. 321, Issue 1, pp. 227-37, (2008) (PubMed).
: "MUC1 expression is repressed by protein inhibitor of activated signal transducer and activator of transcription-y." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 11, pp. 2725-37, (2007) (PubMed).
: "The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through ..." in: The Journal of biological chemistry, Vol. 281, Issue 35, pp. 25850-66, (2006) (PubMed).
: "The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis." in: Molecular cell, Vol. 22, Issue 6, pp. 783-94, (2006) (PubMed).
: "SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3506-18, (2005) (PubMed).
: "PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis." in: FEBS letters, Vol. 570, Issue 1-3, pp. 97-101, (2004) (PubMed).
: "Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y)." in: Molecular endocrinology (Baltimore, Md.), Vol. 18, Issue 8, pp. 1988-99, (2004) (PubMed).
Aliases for PIAS4 抗体
protein inhibitor of activated STAT 4 (PIAS4) 抗体protein inhibitor of activated STAT, 4 (Pias4) 抗体
protein inhibitor of activated STAT, 4a (pias4a) 抗体
protein inhibitor of activated STAT 4 L homeolog (pias4.L) 抗体
protein inhibitor of activated STAT 4 (pias4) 抗体
protein inhibitor of activated STAT 4 (Pias4) 抗体
protein inhibitor of activated STAT, 4b (pias4b) 抗体
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