Phospholamban 产品
(Phospholamban (PLN))
Categories
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].
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Featured Phospholamban Categories
Phospholamban 抗体
High quality antibodies with extensive validation data.
Phospholamban ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Phospholamban 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Phospholamban 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7442687
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, FACS
Validations
- (5)
Cat. No.
ABIN3032226
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN682468
Quantity
100 μL
Datasheet
Datasheet
Recommended Phospholamban ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969290
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958555
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1571936
Quantity
96 tests
Datasheet
Datasheet
Recommended Phospholamban 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315443
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7412563
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7395149
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Phospholamban Products
: "Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and "Reopening"." in: PloS one, Vol. 16, Issue 4, pp. e0250319, (2021) (PubMed).: "Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes." in: Cellular signalling, Vol. 63, pp. 109362, (2019) (PubMed).
: "Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure." in: Circulation, Vol. 138, Issue 11, pp. 1144-1154, (2019) (PubMed).
: "Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation." in: Cellular signalling, Vol. 27, Issue 9, pp. 1807-15, (2015) (PubMed).
: "Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction." in: Molecular and cellular biology, Vol. 32, Issue 4, pp. 740-50, (2012) (PubMed).
: "The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy." in: European journal of heart failure, Vol. 11, Issue 11, pp. 1031-5, (2009) (PubMed).
: "Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes." in: American journal of physiology. Cell physiology, Vol. 296, Issue 5, pp. C992-C1002, (2009) (PubMed).
: "Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 32, Issue 2, pp. 333-9, (2007) (PubMed).
: "Phospholamban: a key determinant of cardiac function and dysfunction." in: Archives des maladies du coeur et des vaisseaux, Vol. 98, Issue 12, pp. 1239-43, (2006) (PubMed).
: "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8016-21, (2005) (PubMed).
Synonyms and alternative names related to Phospholamban
phospholamban (PLN), phospholamban (pln), phospholamban (Pln), cmd1p, CMD1P, CMH18, LOC100226261, plb, PLB, Plb, PlmProtein level used designations for Phospholamban
- phospholamban
- cardiac phospholamban
- PLB
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