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PHLDA3 产品

(Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Categories

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).

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Featured PHLDA3 Categories

PHLDA3 抗体

High quality antibodies with extensive validation data.

PHLDA3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PHLDA3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7247396
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN2452076
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (1)
Cat. No. ABIN7187767
Quantity 100 μg
Datasheet Datasheet

Recommended PHLDA3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314936
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314938
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3085960
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PHLDA3 Products

Kawase, Ohki, Shibata, Tsutsumi, Kamimura, Inazawa, Ohta, Ichikawa, Aburatani, Tashiro, Taya: "PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt." in: Cell, Vol. 136, Issue 3, pp. 535-50, (2009) (PubMed).

Frank, Mendelsohn, Ciccone, Svensson, Ohlsson, Tycko: "A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 12, pp. 1150-9, (2000) (PubMed).

Synonyms and alternative names related to PHLDA3

pleckstrin homology like domain family A member 3 (PHLDA3), pleckstrin homology like domain, family A, member 3 (Phlda3), pleckstrin homology-like domain, family A, member 3 (Phlda3), pleckstrin homology-like domain, family A, member 3 (phlda3), si:dz182n13.5, TIH1, Tih1, zgc:92333

Protein level used designations for PHLDA3

  • pleckstrin homology-like domain, family A, member 3
  • TDAG51/Ipl homolog 1
  • pleckstrin homology-like domain family A member 3
  • pleckstrin homology-like domain, family A, member 2
  • TDAG/lpl homolog 1
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