PFKFB2 抗体
(6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2))
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Datasheet
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Latest Publications for our PFKFB2 抗体
: "Label-free quantitative proteomic analysis of right ventricular remodeling in infant Tetralogy of Fallot patients." in: Journal of proteomics, Vol. 84, pp. 78-91, (2013) (PubMed).: "Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10640-51, (2013) (PubMed).
: "Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells." in: BMC cancer, Vol. 10, pp. 638, (2010) (PubMed).
: "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases." in: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24223-32, (2009) (PubMed).
: "A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells." in: The Biochemical journal, Vol. 411, Issue 1, pp. 41-51, (2008) (PubMed).
: "Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells." in: Oncogene, Vol. 21, Issue 55, pp. 8414-27, (2002) (PubMed).
: "Isolation of novel heart-specific genes using the BodyMap database." in: Genomics, Vol. 74, Issue 1, pp. 115-20, (2001) (PubMed).
Aliases for PFKFB2 抗体
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a (pfkfb2a) 抗体6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) 抗体
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (pfkfb2) 抗体
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (Pfkfb2) 抗体
4930568D07Rik 抗体
PFK-2/FBPase-2 抗体
pfkfb2 抗体
RH2K 抗体
zgc:56282 抗体
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