Hadjipanayis, Machaidze, Kaluzova, Wang, Schuette, Chen, Wu, Mao: "EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma." in: Cancer research, Vol. 70, Issue 15, pp. 6303-12, (2010) (PubMed).
抗原
EGFRviii (EGFRv3)
(EGFR vIII (EGFRv3))
背景
The epidermal growth factor receptor variant III (EGFRvIII) is a consistent tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms. As such it represents a truly tumor-specific target for antitumor immunotherapy.